Nucleic acids of Rochalimaea henselae and methods and compositio

Details Nucleic acids of Rochalimaea henselae and methods and compositio Nucleic acids of Rochalimaea henselae and methods and compositio

1994-09-16

1998-04-07

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 6, 435975, 436811, 5303884, 5303871, 5303895, 5303911, 5303913, G01N 33554, C12Q 168, C07K 1600

Patent

active

057363471

ABSTRACT:
A method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presence of Rochalimaea henselae or an antigenic fragment thereof in the subject is provided. Also provided is a vaccine comprising an immunogenic amount of a nonpathogenic Rochalimaea henselae or an immunogenically specific determinant thereof and a pharmaceutically acceptable carrier. A method of diagnosing Rochalimaea quintana infection in a subject by detecting the presence of a nucleic acid specific to Rochalimaea quintana in a sample from the subject is provided. A purified, 60-kDa heat shock protein of Rochalimaea is provided. Also provided is a 17-kDa antigenic polypeptide of Rochalimaea.

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