Nucleic acids labeled with a chemiluminescent acridine ester

Details Nucleic acids labeled with a chemiluminescent acridine ester Nucleic acids labeled with a chemiluminescent acridine ester

1991-04-08

1992-10-13

Naff, David M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 89, 435 91, 536 23, 536 26, 935 78, C07H 1700, C07H 1906, C12Q 168, C12P 1934

Patent

active

051552167

ABSTRACT:
Polynucleotides are labeled with chemiluminescent acridine esters or luminescent lanthanides. Labelling is preferably carried out by incorporating a functional group into a nucleotide or polynucleotide at the C4 position of the pyrimidine portion or the C6 position of the purine portion and bonding a chemiluminescent acridine ester or a luminescent lanthanide to the functional group. The labeled polynucleotides are useful for direct detection of homologous polynucleotide sequences.

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