Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-11-20
2000-02-08
Wilson, James O.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 221, 536 253, 536 2531, 536 2532, 536 2534, 534 11, 534 13, 534 15, 534 16, 540149, 540465, 540472, C07H 2102
Patent
active
060229594
ABSTRACT:
Texaphyrin metal complex-oligonucleotide and -oligonucleotide analog conjugates are provided where the texaphyrin is bound to an internal linkage of the oligonucleotide or oligonucleotide analog, the conjugates having catalytic activity for the hydrolysis of ribonucleic acid. Further, conjugates demonstrating catalytic turnover are described, the conjugates being especially effective under conditions where the concentration of RNA target exceeds that of available conjugate.
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Crofts Shaun P.
Magda Darren
Wright Meredith
Pharmacyclics Inc.
Wilson James O.
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