Nucleic acids having expression differentials between...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S024300, C536S024310, C435S006120, C435S091100

Reexamination Certificate

active

07358349

ABSTRACT:
A nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:104 in the Sequence Listing and a protein encoded by the nucleic acid, particularly a nucleic acid displaying differential expression levels in hepatoblastoma and normal liver based on comparison therebetween and a protein encoded by the nucleic acid as well as tumor detection utilizing the foregoing.

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Takayasu, et al. “Frequent Deletions and Mutation of the β-CateninGene Are Associated with Overexpression ofCyclin D1andFibronectinand Poorly Differentiated Histology in Childhood Hepatoblastoma1,” Clinical Cancer Research, vol. 7, pp. 901-908, (Apr. 2001).
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Yamada Shin-Ichi et al.; “Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK 1 oncogene as a poor-prognostic indicator of heptoblastomas” ONCOGENE, vol. 23, No. 35, Aug. 5, 2004, pp. 5901-1911.
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Sambrook et al., Molecular Cloning: A Laboratory Manual, Third Edition, 2001, pp. 10.47 and 10.48, vol. 2, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

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