Nucleic acids for the detection of the Bak polymorphism in human

Details Nucleic acids for the detection of the Bak polymorphism in human Nucleic acids for the detection of the Bak polymorphism in human

1994-10-07

1997-07-29

Arthur, Lisa B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 435 6, 935 77, 935 78, C07H 2104, C12Q 168

Patent

active

056523572

ABSTRACT:
Isolated polynucleotide molecules and peptides encoded by these molecules can be used in the analysis of alloantigen phenotypes, as well as in diagnostic and therapeutic applications, relating to human platelet Bak polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from platelet mRNA, it is possible to type glycoprotein GPIIb with regard to the Bak polymorphism, for example, in the context of diagnosing and treating clinical syndromes associated with GPIIb-related immune responses.

REFERENCES:
Poncz et al. (1987, Jun. 25) J. Biol. Chem 262(18):8476-8482.
Hayzer et al. (1994) Gene 151:267-271.
Saiki et al. (1986) Nature 324:163-166.

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