Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1992-06-04
1995-10-03
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4353201, 536 231, 536 235, 536 2431, 536 2433, C12N 510, C12N 1512, C12N 1585
Patent
active
054551692
ABSTRACT:
The invention provides an isolated nucleic acid characteristic of human amyloid precursor protein 770 including the nucleotides encoding codon 670 and 671, wherein the nucleic acid encodes an amino acid other than lysine at codon 670 and/or an amino acid other than methionine at codon 671. Also provided is a method of diagnosing or predicting a predisposition to Alzheimer's disease, comprising detecting in a sample from a subject the presence of a mutation at a nucleotide position corresponding to codons 670 and/or 671 of amyloid precursor protein or fragment thereof, the presence of the mutation indicating the presence of or a predisposition to Alzheimer's disease.
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Alzheimer's Institute of America, Inc.
Walsh Stephen G.
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