Nucleic acids encoding β-1,4-GalNAc transferase

Details Nucleic acids encoding β-1,4-GalNAc transferase Nucleic acids encoding β-1,4-GalNAc transferase

2005-06-28

2005-06-28

Prouty, Rebecca (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S193000, C435S320100, C435S252330, C435S325000, C536S023200

Reexamination Certificate

active

06911337

ABSTRACT:
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example,Campylobacterspecies, includingC. jejuni.In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

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