Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1994-07-25
1996-11-26
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 911, 435 912, 435 9153, 4351723, 4353201, 536 237, 536 2372, 536 2432, 536 2433, C07H 2104, C12P 1934, C12Q 168, C12Q 170
Patent
active
055784488
ABSTRACT:
The present invention provides nucleic acids encoding consensus hemagglutinin and consensus fusion polypeptides which contain at least one amino acid substitution relative to the Moraten vaccine strain that is found in at least one strain of wild-type measles virus. Nucleic acid reagents useful for detecting and differentiating wild-type measles strains by polymerase chain reaction and a method utilizing the same are provided. Recombinant vectors comprising nucleic acids encoding the consensus hemagglutinin and/or the consensus fusion polypeptides are also provided.
REFERENCES:
Cattaneo et al. Cell 55:255-256, 1988.
Gerald et al. J. Gen. Virol. 67:2695-2703, 1986.
Rota et al. Virology 188:135-142, 1992.
Buckland et al. J. Gen. Virology 68:1695-1703, 1987.
Chehab et al. Nature 329:293-294, 1987.
Alkhatlb et al., "The Predicted Primary Structure of the Measles Virus Hemagglutinin," Virology 150: 479-490 (1986) Spec. p. 12. lines 14-18.
Drillien et al., "Protection of mice from fatal measles encephalitis by vaccination with vaccinia virus recombinants encoding either the hemagglutinin or the fusion protein," Proc. Nat'l. Acad. Sci. USA 86: 1252-56 (1988).
Hilleman et al., "Development and Evaluation of the Moraten Measles Virus Vaccine," JAMA 206: 587-90 (1968) Spec. p. 1, lines 14-18.
Richardson et al., "The Nucleotide Sequence of the mRNA Encoding the Fusion Protein of Measles Virus (Edmonston Strain): A comparison of Fusion Proteins from Several Different Paramyxoviruses," Virology 155: 508-523 (1986) Spec. p. 12, lines 15-19.
K. Baczko et al., "Nucleotide sequence of the genes encoding the matrix protein of two wild-type virus strains", J. Gen. Virology, vol. 72, No. 9, Sep. 1991, Soc. Gen. Microbiol., Reading, UK; pp. 2279-2282.
M. J. Taylor et al. "Identification of several different lineages of measles virus", J. Gen. Virology, vol. 72, No. 1, Jan. 1991, Soc. Gen. Microbiol., Reading, UK; pp. 83-88.
R. Cattaneo et al., "Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases", Virology, vol. 173, No. 2, Dec. 1989, Academic Press Ince., NY, U.S; pp. 415-425.
Bellini William J.
Rota Jennifer S.
The United States of America as represented by the Department of
Tran Paul B.
Zitomer Stephanie W.
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