Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-12-05
2000-02-01
Spector, Lorraine
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4353201, 435358, 435325, 4352523, 43525411, 435 691, 536 2351, C12N 1511, C12N 510, C12N 516, C07K 1471
Patent
active
060204737
ABSTRACT:
The present invention involves the preparation of vascular endothelial growth factor (VEGF) variants which provide materials that are selective in respect to binding characteristics to the kinase domain region and the FMS-like tyrosine-kinase region, respectively KDR and FLT-1. The respective KDR and FLT-1 receptors are bound by corresponding domains within the VEGF compound domains. The variants hereof define those two binding regions and modify them so as to introduce changes that interrupt the binding to the respective domain. In this fashion the final biological characteristics of the VEGF molecule are selectively modified.
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Ferrara Napoleone
Keyt Bruce A.
Nguyen Francis Hung
Genentech Inc.
Johnston Sean
Kaufman Claire M.
Spector Lorraine
Vance Dolly A.
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