Nucleic acids encoding trophinin and trophinin-assisting protein

Details Nucleic acids encoding trophinin and trophinin-assisting protein Nucleic acids encoding trophinin and trophinin-assisting protein

1994-10-04

1997-02-04

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 221, 536 243, 536 2431, 536 2433, 435 6, C07H 2102, C07H 2104, C12Q 168

Patent

active

055999182

ABSTRACT:
The present invention provides substantially purified mammalian trophinin which can mediate cell adhesion. The invention also provides substantially purified trophinin-assisting proteins, which interact with trophinin to mediate cell adhesion. The invention also provides antibodies that are specifically reactive with trophinin or a trophinin-assisting protein. The invention further provides a nucleic acid molecule encoding trophinin or a trophinin-assisting protein, vectors containing the nucleic acid molecules and host cells containing the vectors. The invention also provides a nucleotide sequence that can hybridize to a nucleic acid molecule encoding trophinin or a trophinin-assisting protein. The invention further provides methods to detect trophinin or a trophinin-assisting protein or a nucleic acid molecule encoding trophinin or a trophinin-assisting protein in a sample. The invention also provides methods of effecting cell adhesion by modifying cells to express trophinin or a trophinin-assisting protein. The invention further provides trophinin antagonists and methods to reduce or inhibit cell adhesion. The method further provides methods to treat cells with trophinin agonists resulting in increased cell adhesion.

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