Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-07-24
1998-03-31
Degen, Nancy
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4353201, 435325, 536 245, C07H 2104, C12N 510, C12N 1585
Patent
active
057340366
ABSTRACT:
The invention provides a purified polypeptide having substantially the same amino acid sequence and activity as the protein having the amino acid sequence of FIG. 1, or a characteristic fragment thereof. The polypeptide is a transcriptional activator. Nucleic acids encoding the polypeptide and uses are also provided.
REFERENCES:
Leonard Guarente, "UASs and Enhancers: Common Mechanism of Transcriptional Activation in Yeast and Mammals," Cell 52:303-305 (1988).
Karim et al., "The ETS-domain: A New DNA-binding Motif that Recognizes a Purine-rich Core DNA Sequence," Genes & Devel. 4:1451-1453 (1990).
Moreau-Gachelin et al., "The Putative Oncogene Spi-1: Murine Chromosomal Localization and Transcriptional Activation in Murine Acute Erythroleukemias," Oncogene 4:1449-1456 (1989).
Moreau-Gachelin et al., "Spi-1 is a Putative Oncogene in Virally Induced Murine Erythroleukaemias, Nature 331:277-280 (1988).
Moreau-Gachelin et al., "The PU.1 Transcription Factor is the Product of the Putative Oncogene Spi-1," Cell 61:1165-66 (1990).
Pettersson and Schaffner, "A Purine-rich DNA Sequence Motif Present in SV40 and Lymphotropic Papovavirus Binds a Lymphoid-specific Factor and Contributes to Enhancer Activity in Lymphoid Cells," Genes & Devel. 1:962-972 (1987).
Serfling et al., "Ubiquitous and Lymphocyte-specific Factors are Involved in the Induction of the Mouse Interleukin 2 Gene in T Lymphocytes," EMBO Journal 8:465-473 (1989).
Shaw et al., "Indentification of a Putative Regulator of Early T Cell Activation Genes," Science 241:202-205 (1988).
Moreau-Gacheln, et al. 1989. Oncogene, vol. 4, pp. 1449-1456.
Celada Antonio
Klemsz Michael J.
Maki Richard A.
McKercher Scott R.
Degen Nancy
The Burnham Institute
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