Nucleic acids encoding the hypoxia inducible factor-1

Details Nucleic acids encoding the hypoxia inducible factor-1 Nucleic acids encoding the hypoxia inducible factor-1

1995-06-06

1999-03-16

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 435325, 536 235, C12N 120, C12N 1563, C12N 500, C07H 2104

Patent

active

058829148

ABSTRACT:
The purified and characterization of hypoxiainducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1.alpha. and HIF-1.beta.. Purified HIF-1.alpha. polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1.alpha. variant that dimerizes to HIF-1.beta. producing a nonfunctional HIF-1 complex is described. Methods for the prevention and treatment of hypoxia-related disorders are provided.

REFERENCES:
Semenza, J. Mol. Biol., 236:33-48, 1994.
Norris et al., Journal of Biological Chemistry, 40:23774-23779, 1995.
Wang et al., Proceedings of the National Academy of Sciences USA, 92:5510-5514, 1995.
Benjamin et al., Proceedings of the National Academy of Sciences USA, 87:6263-6267, 1990.
Fujiwara et al. Expressed Sequence Tag (EST), GenBank Accession Numbers D56430, D53682, R71408, T32121, HS14513, T32145, M85743, R71117, T32012, and Q60265. GenBank. 30 May 1995 see sequence alignments.

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