Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-04-08
1998-11-17
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352523, 4353201, 536 235, 536 2431, C07H 2104, C12N 1512
Patent
active
058375210
ABSTRACT:
The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.
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Cone Roger D.
Mountjoy Kathleen G.
Robbins Linda S.
Roselli-Rehfuss Linda
Allen Marianne P.
Spector Lorraine
State of Oregon
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