Nucleic acids encoding sodium channel scn3a alpha subunits

Details Nucleic acids encoding sodium channel scn3a alpha subunits Nucleic acids encoding sodium channel scn3a alpha subunits

2003-09-17

2009-02-03

Kolker, Daniel E. (Department: 1649)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S254200, C435S320100, C536S023500

Reexamination Certificate

active

07485449

ABSTRACT:
The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome 2, which show mutations in patients with epilepsy. The invention further relates to nucleic acid sequences, and protein sequences of these loci (SCNA) and to the use thereof to assess, diagnose, prognose or treat epilepsy, to predict an epileptic individual's response to medication and to identify agents which modulate the function of the SCNA. The invention also provides screening assays using SCN1A, SCN2A and/or SCN3A which can identify compounds which have therapeutic benefit for epilepsy and related neurological disorders.

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