Nucleic acids encoding PTH functional domain conjugate peptides

Details Nucleic acids encoding PTH functional domain conjugate peptides Nucleic acids encoding PTH functional domain conjugate peptides

2007-07-17

2007-07-17

Li, Ruixiang (Department: 1646)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023510, C530S399000

Reexamination Certificate

active

11366391

ABSTRACT:
Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and PTH(1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.

REFERENCES:
patent: 4086196 (1978-04-01), Tregear
patent: 4675189 (1987-06-01), Kent et al.
patent: 4698328 (1987-10-01), Neer et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4761406 (1988-08-01), Flora et al.
patent: 5527772 (1996-06-01), Holick
patent: 5556940 (1996-09-01), Willick et al.
patent: 5840690 (1998-11-01), Holick
patent: 5977070 (1999-11-01), Piazza et al.
patent: 6417333 (2002-07-01), Bringhurst et al.
patent: 6495662 (2002-12-01), Gardella et al.
patent: 6537965 (2003-03-01), Bringhurst et al.
patent: 6541220 (2003-04-01), Juppner et al.
patent: 0 561 412 (1993-09-01), None
patent: 2269176 (1994-02-01), None
patent: WO 95/11988 (1995-05-01), None
Abou-Samra, A.-B., et al., “Non-Homologous Sequences of Parathyroid Hormone and the Parathyroid Hormone Related Peptide Bind to a Common Receptor on ROS 17/2.8 Cells,”Endocrinology 125:2215-2217, Endocrine Society (1989).
Azarani, A., et al., “Structurally Diverse N-terminal Peptides of Parathyroid Hormone (PTH) and PTH-related Peptide (PTHRP) Inhibit the Na+/H+Exchanger NHE3 Isoform by Binding to the PTH/PTHRP,”J. Biol. Chem. 271:14931-14936, The American Society for Biochemistry and Molecular Biology, Inc. (1996).
Bergwitz, C., et al., “Full Activation of Chimeric Receptors by Hybrids between Parathyroid Hormone and Calcitonin,”J. Biol. Chem. 271:26469-26472, The American Society for Biochemistry and Molecular Biology, Inc. (1996).
Bergwitz, C., et al., “Residues in the Membrane-spanning and Extracellular Loop Regions of the Parathyroid Hormone (PTH)-2 Receptor Determine Signaling Selectivity for PTH and PTH-related Peptide,”J. Biol. Chem. 272:28861-28868, The American Society for Biochemistry and Molecular Biology, Inc. (1997).
Bisello, A., et al., “Parathyroid Hormone-Receptor Interactions Identified Directly by Photocross-linking and Molecular Modeling Studies,”J. Biol. Chem. 273:22498-22505, The American Society for Biochemistry and Molecular Biology, Inc. (Aug. 1998).
Broadus, A.E., and Stewart, A.F., “Parathyroid Hormone-Related Protein Structure, Processing and Physiological Actions,” inThe Parathyroids Basic and Clinical Concepts, Bilezikian, J.P., et al., eds., Raven Press Ltd., New York, NY, pp. 259-294 (1994).
Caulfield, M.P., et al., “The Bovine Renal Parathyroid Hormone (PTH) Receptor Has Equal Affinity for Two Different Amino Acid Sequences: The Receptor Binding Domains of PTH and PTH-Related Protein Are Located within the 14-34 Region,”Endocrinology 127:83-87, Endocrine Society (1990).
Cleland, J.L., et al., “The Development of Stable Protein Forumlations: A Close Look at Protein Aggregation, Deamidation, and Oxidation,”Crit. Rev. Ther. Drug Carrier Sys. 10:307-377, Begell House (1993).
Cohen, F.E., et al., “Analogues of Parathyroid Hormone Modified at Positions 3 and 6,”J. Biol. Chem. 266:1997-2004, The American Society of Biochemistry and Molecular Biology (1991).
Colquhoun, D., “Binding, gating, affinity, and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors,”Br. J. Pharmacol. 125:924-947, Nature Publishing Group (Nov. 1998).
Dautzenberg, F.M., et al., “Mapping of the ligand-selective domain of theXenopus laeviscorticotropin-releasing factor receptor 1: Implications for the ligand-binding site,”Proc. Natl. Acad. Sci. USA 95:4941-4946, National Academy of Sciences (Apr. 1998).
Dempster, D. W., et al., “Anabolic Actions of Parathyroid Hormone on Bone,”Endocrine Rev. 14:690-709, The Endocrine Society (1993).
Dempster, D.W., et al., “Anabolic Actions of Parathyroid Hormone on Bone (Erratum),”Endocrine Rev. 15:261, The Endocrine Society (1994).
Gardella, T.J., et al., “Mutational Analysis of the Receptor-activating Region of Human Parathyroid Hormone,”J. Biol. Chem. 266:13141-13146, The American Society for Biochemistry and Molecular Biology (1991).
Gardella, T.J., et al., “Analysis of Parathyroid Hormone's Principal Receptor-Binding Region by Site-Directed Mutagenesis and Analog Design,”Endocrinology 132:2024-2039, The Endocrine Society (1993).
Gardella, T.J., et al., “Determinants of [Arg2]PTH-(1-34) Binding and Signaling in the Transmembrane Region of the Parathyroid Hormone Receptor,”Endocrinology 135:1186-1194, The Endocrine Society (1994).
Gardella, T.J., et al., “Parathyroid Hormone (PTH)-PTH-related Peptide Hybrid Peptides Reveal Functional Interactions between the 1-14 and 15-34 Domains of the Ligand,”J. Biol. Chem. 270:6584-6588, The American Society for Biochemistry and Molecular Biology (1995).
Gardella, T.J., et al., “Converting Parathyroid Hormone-related Peptide (PTHrP) into a Potent PTH-2 Receptor Agonist,”J. Biol. Chem. 271:19888-19893, The American Society for Biochemistry and Molecular Biology (1996).
Goltzmann, D., et al., “Analysis of the Requirements for Parathyroid Hormone Action in Renal Membranes with the Use of Inhibiting Analogues,”J. Biol. Chem. 250:3199-3203, The American Society for Biochemistry and Molecular Biology (1975).
Gombert, F.O., et al., “Alanine and D-Amino Acid Scan of Human Parathyroid Hormone,” inPeptides: Chemistry, Structure and Biology, Pravin, et al., eds., Mayflower Scientific Ltd., Switzerland, pp. 661-662 (1996).
Goud, N.A., et al., “Solid-Phase Synthesis and Biologic Activity of Human Parathyroid Hormone (1-84),”J. Bone Miner. Res. 6:781-789, American Society for Bone and Mineral Research (1991).
Holtmann, M.H., et al., “Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptide Receptors,”J. Biol. Chem. 270:14394-14398, The American Society for Biochemistry and Molecular Biology (1995).
Horiuchi, N., et al., “A Parathyroid Hormone Inhibitor in vivo: Design and Biological Evaluation of a Hormone Analog,”Science 220:1053-1055, American Association for the Advancement of Science (1993).
Ishihara, T., et al., “Molecular cloning and expression of a cDNA encoding the secretin receptor,”EMBO J. 10:1635-1641, Oxford University Press (1991).
Iwakura, M., and Nakamura, T., “Effects of the length of a glycine linker connecting the N-and C-termini of a circularly permuted dihydrofolate reductase,”Protein Engineering 11:707-713, Oxford University Press (Aug. 1998).
Jelinek, L.J., et al., “Expression Cloning and Signaling Properties of the Rat Glucagon Receptor,”Science 259:1614-1616, American Association for the Advancement of Science (1993).
Jüppner, H., et al., “The Parathyroid Hormone-like Peptide Associated with Humoral Hypercalcemia of Malignancy and Parathyroid Hormone Bind to the Same Receptor on the Plasma Membrane of ROS 17/2.8 Cells,”J. Biol. Chem. 263:8557-8560, The American Society for Biochemistry and Molecular Biology (1988).
Jüppner, H., et al., “The Extracellular Amino-Terminal Region of the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Determines the Binding Affinity for Carboxyl-Terminal Fragments of PTH-(1-34),”Endocrinology 134:879-884, The Endocrine Society (1994).
Karaplis, A.C., et al., “Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene,”Genes&Dev. 8:277-289, Cold Spring Harbor

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