Nucleic acids encoding protein tyrosine kinases

Details Nucleic acids encoding protein tyrosine kinases Nucleic acids encoding protein tyrosine kinases

2006-04-25

2006-04-25

Murphy, Joseph (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S006120, C435S320100, C435S325000, C530S350000, C536S023500

Reexamination Certificate

active

07033796

ABSTRACT:
The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.

REFERENCES:
patent: 5185438 (1993-02-01), Lemischke
patent: 5530101 (1996-06-01), Queen et al.
patent: 5677144 (1997-10-01), Ullrich et al.
patent: 5972337 (1999-10-01), Ceriani et al.
patent: 455460 (1991-11-01), None
patent: 519869 (1992-12-01), None
patent: WO 92/13948 (1992-08-01), None
patent: WO 92/14748 (1992-09-01), None
patent: WO 93/00425 (1993-01-01), None
patent: WO 93/14124 (1993-07-01), None
patent: WO 93/15201 (1993-08-01), None
patent: WO 93/23429 (1993-11-01), None
patent: WO 94/19463 (1994-09-01), None
patent: WO 98/34954 (1998-08-01), None
Yan et al., Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. 290: 523-527, 2000.
Mickle JE et al. Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am. May 2000;84(3):597-607.
Voet et al. Biochemistry. 1990. John Wiley & Sons, Inc. pp. 126-128 and 228-234.
Eck & Wilson in Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, McGraw-Hill New York, 1996.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics, Jun. 1998, vol. 14, No. 6, pp. 248-250.
Brenner et al., Errors in Genome Annotation. Trends in Genetics, 1999, 15: 132-133.
Bork et al., Go Hunting in sequence databases but watch out for the traps, Trends in Genetics, 1996, 12: 425-427.
“Chapter 16: Expression of Cloned Genes in Cultured Mammalian Cells”Molecular Cloning: A Laboratory Manual, Sambrook et al., Second edition, Cold Spring Harbor Laboratory Press vol. 3: 16.2-16.30 (1989).
“Chapter 17: Expression of Cloned Genes inEscherichia coli”, Molecular Cloning: A Laboratory Manual, Sambrook et al., Second edition, Cold Spring Harbor Laboratory Press vol. 3:17.2-17.28 (1989).
Aroian et al., “The let-23 Gene Necessary forCaenorhabditis elgansVulval Induction Encodes a Tyrosine Kinase of the EGF Receptor Subfamily”,Nature348:693-699 (1990).
Birchmeier et al., “Characterization of an Activated Human ros Gene” ,Molecular&Cellular Biology6(9): 3109-3116 (1986).
Brauninger et al., “Isolation and Characterization of a Human Gene That Encodes a New Subclass of Protein Tyrosine Kinases”,Gene110(2): 205-211 (1992).
Capon et al., “Designing CD4 Immunoadhesins for AIDS Therapy”,Nature337:525-531 (Feb. 9, 1989).
Dai et al., “Molecular Cloning of a Novel Receptor Tyrosine Kinase, tif, Highly Expressed in Human Ovary and Testis”,Oncogene9: 975-979 (1994).
Duan et al., “A Functional Soluble Extracellular Region of the Platelet-derived Growth Factor (PDGF) β-Receptor Antagonized PDGF-stimulated Responses”,Journal of Biological Chemistry266(1): 413-418 (Jan. 5, 1991).
Faust et al., “The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis”,Oncogene7:1287-1293 (1992).
Fujumoto, “brt, A Mouse Gene Encoding a Novel Receptor-Type Protein-Tyrosine Kinase, is Preferentially Expressed in the Brain”,Oncogene9:693-698 (1994).
GenBank, “Release 79” (along with hystyro3 and hstyro3y sequences available on GenBank) (Oct. 15, 1993).
Godowski et al., “Reevaluation of the Roles of Protein S and Gas6 as Ligands for the Receptor Tyrosine Kinase Rse/Tyro3”,Cell82:355-358 (Aug. 11, 1995).
Hanks et al., “The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains”,Science241:42-52 (1988).
Hao et al, “Isolation and Sequence Analysis of a Novel Human Tyrosine Kinase Gene”,Molecular&Cellular Biology94(4): 1587-1593 (1989).
Hart et al., “Extracellular Domain of the Boss Transmembrane Ligand Acts as an Antagonist of the Sev Receptor”,Nature361:732-736 (1993).
Holtrich et al., “Two Additional Protein-Tyrosine Kinases Expressed in Human Lung: Fourth Member of the Fibroblast Growth Factor Receptor Family and an Intracellular Protein-Tyrosine”,Proc. Natl. Acad. Sci. 88:10411-10415 (1991).
Janssen et al., “A novel putative tyrosine kinase receptor with oncogenic potential”,Oncogene6:2113-2120 (1991).
Johnson et al., “A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain”,Proc. Natl. Acad. Sci, 90:5677-5681 (Jun. 15, 1993).
Lai et al., “An Extended Family of Protein-Tyrosine Kinase Genes Differentially Expressed in the Vertebrate Nervous System”,Neuron6:691-704 (May 1991).
Lai et al., “Structure, Expression, and Activity of Tyro 3, a Neural Adhesion-related Receptor Tyrosine Kinase”,Oncogene9:2567-2578 (1994).
Li et al., “Identification of Gas6 as a Growth Factor for Human Schwann Cells”,The Journal of Neuroscience16(6):2012-2019 (Mar. 15, 1996).
Mark et al., “rse, a Novel Receptor-type Tyrosine Kinase with Homology to Axl/Ufo, Is Expressed at High Levels in the Brain”,Journal of Biological Chemistry269(14):10720-10728 (Apr. 8, 1994).
Martin-Zanca et al., “Molecular and Biochemical Characterization of the Human trk Proto-Oncogene”,Molecular&Cellular Biology9(1):24-33 (Jan. 1989).
Matthews et al, “A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit”,Proc. Natl. Acad. Sci. 88:9026-9030 (1991).
Matthews et al., “A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations”,Cell65:1143-1152 (1991).
Ohashi et al., “Cloning of the cDNA for a Novel Receptor Tyrosine Kinase, Sky, Predominantly Expressed in Brain”,Oncogene9:699-705 (1994).
Ohashi et al., “Cloning of the cDNA for a Novel Receptor Tyrosine Kinase, Sky, Predominantly Expressed in Brain”,Oncogene9:699-705 (1994).
Paborsky et al., “Mammalian Cell Transient Expression of Tissue Factor for the Production of Antigen”,Protein Eng. 3(6):547-553 (1990).
Park et al., “Sequence of MET Protooncogene cDNA has Features Characteristic of the Tyrosine Kinase Family of Growth-Factor Receptors”,Proc. Natl. Acad. Sci. USA84:6379-6383 (1987).
Partanen et al., “Putative Tyrosine Kinases Expressed in K-562 Human Leukemia Cells”,Proc. Natl. Acad. Sci. 87:8913-8917 (1990).
Pazin et al., “Triggering Signaling Cascades by Receptor Tyrosine Kinases”,TIBS17:374-378 (1992).
Polvi et al., “The Human TYRO3 Gene and Pseudogene are Located in Chromosome 15q14-q25”,Gene134:289-293 (1993).
Pulido et al., “Etrk, a Drosophilia Gene Related to the trk Family of Neurotrophin Receptors, Encodes a Novel Class of Neural Cell Adhesion Molecule”,EMBO Journal11(2):391-404 (1992).
Rescigno et al., “A putative receptor tyrosine kinase with unique structural topology”,Oncogene6:1909-1913 (1991).
Sarup, “Characterization of an Anti-P185ner2Monoclonal Antibody that Stimulates Receptor Function and Inhibits Tumor Cell Growth”,Growth Regulation1:72-82 (1991).
Schlessinger et al., “Growth factor signaling by receptor tyrosine kinases”,Neuron9:383-391 (1992).
Stark et al., “FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse”,Development113:641-651 (1991).
Taylor et al., “Mouse Mammary Tumors Express Elevated Levels of RNA Encoding the Murine Homolog of SKY, a Putative Receptor Tyrosi

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