Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-03-08
2011-03-08
Zeman, Robert A (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S023200, C530S350000
Reexamination Certificate
active
07902349
ABSTRACT:
Purified nucleic acids comprising a nucleotide sequence encoding an immunogenic polypeptide of adenyl cyclase-haemolysin (AC-Hly), which induces formation of protective antibodies against an infection by a bacteria selected from the group consisting ofB. pertussis, B. parapertussis, andB. bronchisepticawhen the nucleic acid or polypeptide is administered to a human or animal host. The nucleic acids are useful, for example, to induce a protective immune response in a host against infection by a bacteria selected from the group consisting ofB. pertussis, B. parapertussis, andB. bronchiseptica.
REFERENCES:
patent: 5095094 (1992-03-01), Brezsin et al.
patent: 5183745 (1993-02-01), Danchin et al.
patent: 5595901 (1997-01-01), Rocancourt et al.
patent: 0 162 639 (1985-11-01), None
patent: 0162639 (1985-11-01), None
patent: 0 235 474 (1987-09-01), None
patent: 0 275 689 (1988-07-01), None
patent: 0 338 170 (1989-10-01), None
patent: 0338 170 (1989-10-01), None
patent: 2 606 789 (1988-05-01), None
patent: WO 90/13312 (1990-11-01), None
Colman (Res. Immunology, Jan. 1994, vol. 145, pp. 33-36).
Greenspan et al. (Nature Biotechnology 17: 936-937, 1999).
Betsou, Fotini, et al., “The C-Terminal Domain is Essential for Protective Activity of theBordetella pertussisAdenylate Cyclase-Hemolysin,”Infection and Immunity, vol. 53, No. 9, pp. 3309-3315 (Sep. 1995).
Burnette et al., “Pertussis Toxin S1 Mutant with Reduced Enzyme Activity and a Conserved Protective Epitope,”Science, 242, pp. 72-74 (1988).
Ladant, Daniel, et al., “Bordetella pertussisAdenylate Cyclase,”J. Biol. Chem., 261, vol. 34, pp. 16264-16269 (1986).
Tippetts et al., “Molecular Cloning and Expression of theBacillus anthracisEdema Factor Toxin Gene: a Calmodulin-Dependent Adenylate Cyclase,”J. Bacteriol., 170, vol. 5, pp. 2263-2266 (1988).
Weiss et al., “Tn5-Induced Mutations Affecting Virulence Factors ofBordetella pertussis,” Infection and Immunity, 42, pp. 33-41 (1983).
Glaser, P., et al., “Identification of Residues Essential for Catalysis and Binding of Calmodulin inBordetella pertussisAdenylate Cyclase by Site-directed Mutagenesis,”EMBO Journal, 8, vol. 3, pp. 967-972 (1989).
Glaser, P., et al., “The Calmodulin-Sensitive Adenylate Cyclase ofBordetella pertussis: Cloning and Expression inEscherichia coli,” Molecular Microbiology, 2, vol. 1, pp. 19-30 (1988).
Au et al., “Site-Directed Mutagenesis of Lysine 58 in a Putative ATP-Binding Domain of the Calmodulin-Sensitive Adenylate Cyclase fromBordetella pertussisAbolishes Catalytic Activity,”Biochemistry, 28, pp. 2772-2776 (1989).
Guiso, N., et. al., “Bordetellaadenylate cyclase is a virulence associated factor and an immunoprotective antigen,”Microbial Pathogenesis, 7, pp. 373-380 (1989).
Ladant, D., “Interaction ofBordetella pertussisAdenylate Cyclase with Calmodulin,”The Journal of Biology Chemistry, vol. 263, No. 6, Issue of Feb. 25, pp. 2612-2618 (1988).
Holland, M., “Isolation and Characterization of a Small Catalytic Domain Released from the Adenylate Cyclase fromEscherichia coliby Digestion with Trypsin,”The Journal of Biological Chemistry, vol. 263, Issue of Oct. 15, pp. 14661-14668 (1988).
Glaser, P., et al., Abstract, “The calmodulin-sensitive adenylate cyclase ofBordetella pertussis: cloning and expression inEscherichia coli,” Chemical Abstracts, vol. 112 (1990).
European Search Report dated Feb. 22, 1990, for EP 89 40 2948.
Beattie, David, et al., “Repressor Binding to a Regulator Site in the DNA Coding Sequence is Sufficient to Confer Transcriptional Regulation of thevirr-Repressed Genes (vrgGenes) inBordetella pertussis,” Journal of Bacteriology, vol. 175, No. 2, pp. 519-527 (Jan. 1993).
Betsou, Fotini, “Cyac-Mediated Activation is Important Not Only for Toxic but Also for Protective Activities ofBordetella pertussisAdenylate Cyclase-Hemolysin,”Infection and Immunity, vol. 61, No. 9, pp. 3583-3589 (Sep. 1993).
Gross, Mary K., et al., “Targeted Mutations that Ablate Either the Adenylate Cyclase or Hemolysin Function of the Bifunctional cyaA toxin ofBordetella pertussisAbolish Virulence,”Proc. Nat'l . Acad. Sci., vol. 89, pp. 4898-4902 (Jun. 1992).
Hackett, Murray, et al., “Internal Lysine Palmitoylation in Adenylate Cyclase Toxin fromBordetella pertussis,” Science, vol. 266, pp. 433-435 (Oct. 1994).
Bartoloni et al.,Tokai J. Exp. Clin. Med., 13 (Suppl.), pp. 217-222 (1988).
Beattie, David, et al., “Avir-Repressed Gene ofBordetella pertussisis Required for Virulence,”Infect. &Immun., vol. 60, No. 2, pp. 571-577 (Feb. 1992).
Beattie, David, et al.,J. Bacteriol, vol. 172, No. 12, pp. 6997-7004 (1990).
de Rossi et al.,Vet. Microbiol., vol. 56, pp. 65-77 (1997).
Goldman et al.,Embo Journal, vol. 3, No. 6, pp. 1353-1356 (1984).
Grimprel et al.,Clin.&Diagn. Lab. Immunol., vol. 3, No. 1, pp. 93-97 (1996).
Gueirard et al.,Scan. J. Immunol., No. 43, pp. 181-192 (1996).
Gueirard et al.,J. Clin. Microbiol., vol. 33, No. 8, pp. 2002-2006 (1995).
Gierard et al., In: Bacterial Protein Toxins ed. Freer et al., pp. 152-153 (1994).
Gueirard et al., “Virulence ofBordetella bronchiseptica: Role of Adenylate Cyclase-Hemolysin,”Infect. &Immun., vol. 61, No. 10, pp. 4072-4078 (1993).
Guiso, N., et al.,Microbiol. Pathogenesis, vol. 11, pp. 423-431 (1991).
Hausman et al.,Inf. &Imm., vol. 64, No. 10, pp. 4020-4026 (1996).
Horiguchi et al.,Inf. &Imm., vol. 59, No. 3, pp. 1112-1116 (1991).
Khelef, Nadia, et al., “Characterization of Murine Lung Inflammation after Infection with ParentalBordetella pertussisand Mutants Deficient in Adhesins or Toxins,”Inf. &Imm., vol. 62, No. 7, pp. 2893-2900 (1994).
Khelef, Nadia, et al., In: Bacterial Protein Toxins ed. Freer et al., pp. 514-515 (1994).
Khelef, Nadia, et al., “Both adenylate cyclase and hemolytic activities are required byBordetella pertussisto initiate infection,”Microbiol. Pathogenesis, vol. 12, pp. 227-235 (1992).
Khelef, Nadia, et al.,Infection&Immunity, vol. 61, No. 2, pp. 486-490 (1993).
Knapp et al., “Two trans-Acting Regulatory Genes (virandmod) Control Antigenic Modulation inBordetella pertussis,” J. Bacteriol, 170, No. 11, pp. 5059-5066 (1988).
LeBlay et al.,Microbiology, vol. 143, pp. 1433-1441 (1997).
Munoz et al.,Infection&Immunity, vol. 32, No. 1, pp. 243-250 (1981).
Nakase et al., “Bestandteile vonBordetella pertussis. Besonders Über Die Schutzsubstanz,”Chem. Zentralblatt NR, 8-1284, p. 2576 (1966).
Pittman,Rev. Infectious Disease, vol. 1, No. 3, pp. 401-412 (1979).
Novotny et al., “Adenylate Cyclase Activity of a 68,000-Molecular-Weight Protein Isolated from the Outer Membrane ofBordetella bronchiseptica,” Infection&Immunity, vol. 50, No. 1, pp. 199-206 (Oct. 1985).
Brennan et al., “Identification of a 69-Kilodalton Nonfimoral protein As an Aggulutinogen ofBordetella pertussis,” Infection&Immunity, vol. 56, No. 12, pp. 3189-3195 (Dec. 1988).
Charles et al., “Molecular cloning and characterization of protective outer membrane protein P.69 fromBordetella pertussis,” Proc. Nat'l. Acad. Sci. USA, vol. 86, pp. 3554-3558 (May 1989).
Novotny et al., “Biologic and Protective Properties of the 69-kDa Outer Membrane Protein ofBordetella pertussis: A Novel Formulation for an Acellular Pertussis Vaccine,”J. Infectious Diseases, pp. 114-122 (1991).
Karger, S., Basel, “Bordetella Adenylate Cyclase: A Genus Specific Protective Antigen and Virulence Factor,” Proceedings of the Fourth International Symposium on Pertussis,Dev. Biol. Standard, vol. 61, pp. 27-41 (1985).
Kessin et al., “Secreted Adenylate Cyclase ofBordetella pertussis: Calmodulin Requirements and Partial Purification of Two Forms,”J. Bacteriology, pp. 290-296 (Apr. 1986).
Friedman, “Bordetella pertussisAdenylate Cylcase: Isolation
Betsou Fotini
Guiso Nicole
Sebo Peter
Finnegan Henderson Farabow Garrett & Dunner LLP
Institut Pasteur
Zeman Robert A
LandOfFree
Nucleic acids encoding protective epitopes of adenyl... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acids encoding protective epitopes of adenyl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding protective epitopes of adenyl... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2638891