Nucleic acids encoding potassium-channel proteins

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 231, 536 235, 4353201, 4352523, 43525411, 435325, 435410, C12N 1512, C12N 1563, C12N 121, C12N 510

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active

059170271

ABSTRACT:
The present invention provides DNAs of h.beta.IR and m.beta.IR, which are novel ATP-sensitive potassium channels being present specifically in the pancreatic cells, and proteins encoded by such DNAs, wherein by utilizing them, it is possible to produce said proteins in large quantities through the known genetic engineering techniques for use as a reagent in the research work as well as in the diagnosis and therapy for diabetes and other diseases.

REFERENCES:
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FEBS LETT, Jun. 26, 1995, 367, P193-7, Netherlands, XP002019858 Sakura H et al: "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit.".
Diabetes, May 1995, 44 (5) P592-6, United States, XP000611937, Tsaur ML et al: "Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM."
Biochem Biophys Res Commun, Jul. 26, 1995, 212 (3) P894-9, United States, XP002019859, Stoffel M et al: "Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats."
J. Biol Chem, Mar. 17, 1995, 270 (11) P5691-4, United States, XP002019860, Susumu Seino Inohana Shukusha Chiba University: "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart."
Science, Apr. 21, 1995, 268 (5209) P423-6, United States,XP 002019861; Aguilar-Bryan L et al: "Cloning of the beta cell high-affinity
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