Nucleic acids encoding pancreatic islet cell antigens obtained b

Details Nucleic acids encoding pancreatic islet cell antigens obtained b Nucleic acids encoding pancreatic islet cell antigens obtained b

1995-06-06

1999-09-21

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 435325, 536 235, 530350, C12N 120, C12N 1500, C07H 1700, C07K 1400

Patent

active

059553456

ABSTRACT:
Pancreatic islet cell antigens (ICA) that bind with antibodies found in the sera of patients afflicted with insulin-dependent (Type I) diabetes mellitus (IDDM). ICA proteins are expressed by recombinant cloning vehicles comprising DNA inserts isolated from islet cells. Full sequence native ICA proteins, or protein or peptide fragments thereof, can be used in the diagnosis of IDDM and in detecting or blocking human immunoglobulin, T-cells, or B-cells involved in IDDM.

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