Nucleic acids encoding p53 mutations which suppress p53 cancer m

Details Nucleic acids encoding p53 mutations which suppress p53 cancer m Nucleic acids encoding p53 mutations which suppress p53 cancer m

1997-02-05

1998-11-24

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352542, 4353201, 536 231, C12W 500, C12W 114, C07H 1700

Patent

active

058405798

ABSTRACT:
Intragenic suppressor mutations of common p53 mutations are able to function in cis and/or trans. These mutations are useful for identifying small molecule drugs which function in a similar fashion. In addition, the mutations themselves may be useful therapeutically, especially if they function in trans. Methods for rapidly obtaining this type of mutant employ a yeast selection system. Cells having both the negative mutation and intragenic suppressor are useful for studying the interactions of the two, in particular in determining the structure of the homotetramers and heterotetramers.

REFERENCES:
Wieczorek et al., "Structure-Based Rescue of Common Tumor-Derived p53 Mutants", Nature Medicine 2(10):1143-1146 (1996).
Freeman et al., "Mutation of Conserved Domain II Alters the Sequence Specificity of DNA Binding by the p53 Protein", EMBO Journal 13(22):5393-5400 (1994).
Buchman et al. 1988 Gene 70:245-252.
Nigro et al 1989 Nature 342:705-708.

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