Nucleic acids encoding osteogenic proteins

Details Nucleic acids encoding osteogenic proteins Nucleic acids encoding osteogenic proteins

1994-05-23

1999-01-26

Loring, Susan A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352351, 4353201, 4352523, 536 231, 536 234, C12P 2106, C12N 700, C12N 1500, C12N 120

Patent

active

058637583

ABSTRACT:
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.

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