Nucleic acids encoding novel regulators of G-protein signaling

Details Nucleic acids encoding novel regulators of G-protein signaling Nucleic acids encoding novel regulators of G-protein signaling

1997-03-31

1999-03-16

Teng, Sally P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4352523, 43525411, 4353201, 435325, 536 235, 536 2431, C12N 1512

Patent

active

058828907

ABSTRACT:
The present invention provides two regulators of G-protein signaling (designated individually as RGPS-1 and RGPS-2, and collectively as RGPS) and polynucleotides which identify and encode RGPS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing RGPS and for treating or preventing disorders associated with expression of RGPS.

REFERENCES:
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Druey, K.M. et al., "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family", Nature, 379: 742-746 (1996).
Hong, J.X. et al., J.X. et al., "Isolation and Characterization of a Novel B Cell Activation Gene", J. Immunol., 150: 3895-3904 (1993) (GI 299705).
Siderovski, D.P. et al., "A Human Gene Encoding a Putative Basic Helix-Loop-Helix Phosphoprotein Whose mRNA Increases Rapidly in Cycloheximide-Treated Blood Mononuclear Cells", DNA Cell Biol., 13: 125-147 (1994).
Druey, K., (Direct Submission), GenBank Sequence Database (Accession U27768), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1216373).

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