Nucleic acids encoding novel proteins which bind to retinoblasto

Details Nucleic acids encoding novel proteins which bind to retinoblasto Nucleic acids encoding novel proteins which bind to retinoblasto

1993-08-12

2000-06-06

Teng, Sally

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4352542, 4353201, 435325, 536 235, 536 2431, C12H 1512

Patent

active

060717157

ABSTRACT:
The retinoblastoma protein (Rb) is the product of the retinoblastoma gene and has been found to contain mutations in retinoblastoma tumor cells. Two nuclear proteins that bind to Rb, p48 and p46 have been isolated and the genes have been cloned. These proteins bind to Rb competitively with the SV40 T antigen. p48 is shown to suppress heat shock sensitive Ras mutations in yeast and is implicated as a modulator of the retinoblastoma suppressor function of Rb.

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