Nucleic acids encoding novel orphan cytokine receptors

Details Nucleic acids encoding novel orphan cytokine receptors Nucleic acids encoding novel orphan cytokine receptors

1998-01-22

2000-05-09

Teng, Sally P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 4352523, 4352542, 4353201, 435325, 435348, C12N 1512, C07K 14705

Patent

active

060602767

ABSTRACT:
The present invention provides for nucleic acid sequences that encode novel mammalian receptor polypeptides, designated OCR1. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the MAMMALIAN OCR1 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between MAMMALIAN OCR1 and agents that initiate signal transduction through binding to MAMMALIAN OCR1. In a specific embodiment, the MAMMALIAN OCR1 may HUMAN OCR1 or MOUSE OCR1.

REFERENCES:
Vigon et al., Proc. Natl. Acad. Sci., 89, 5640-5644, Jun. 1992.
Sambrook et al., Molecular Cloning, A Laboratory Manual, Vol. 3, 16.20-16.30 and 17.3-17.28, 1989.

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