Nucleic acids encoding neural axon outgrowth modulators

Details Nucleic acids encoding neural axon outgrowth modulators Nucleic acids encoding neural axon outgrowth modulators

1993-11-12

1996-10-15

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 4352402, 4353201, 536 235, C12N 1500, C12N 1512, C12N 510

Patent

active

055653316

ABSTRACT:
A novel classes of neural axon outgrowth promoting and orienting proteins, nucleic acids encoding such proteins and receptors which selectively bind such proteins are disclosed. The disclosed neural axon outgrowth promoting and orienting proteins include the laminin-related p75/p78 family; a family of vertebrate proteins which promote axon outgrowth and/or orientation, and p75/p78 family-specific receptors, including receptors found on spinal nerve axons, especially growth cones. Also disclosed are agents including peptides derived from the disclosed neural axon outgrowth promoting proteins capable of effecting axon outgrowth, orientation and regeneration. These agents provide small molecular weight modulators of nerve cell growth useful in the treatment of neurological disease and injury. The disclosed compositions also find use variously in screening chemical libraries for regulators of axon outgrowth and orientation, in genetic mapping, as probes for related genes, as diagnostic reagents for genetic neurological disease and in the production of specific cellular and animal systems for the development of neurological disease therapy.

REFERENCES:
Gunderson and Barrett, "Characterization of the Turning Response of Dorsal Root Neurites toward Nerve Growth Factor", J. of Cell Biology 87:546-554 (1980).
Ishii et al., "UNC-6, a Laminin-Related Protein, Guides cell and Pioneer Axon Migrations in C. elegans", Neuron 9:873-881 (1992).
Lohof et al., "Asymmetric Modulation of Cytosolic CAMP Activity Induces Growth Cone Turning", J. of Neuroscience 12(4):1253-1261 (1992).
Placzek et al., "Guidance of Developing Axons by Diffusible Chemoattractants", Cold Spring Harbor Symposia on Quantitative Biology LV:279-289 (1990).
Placzek et al., "Orientation of Commissural Axons in vitro in Response to a Floor Plate-derived Chemoattractant", Development 110:19-30 (1990).
Tessier-Lavigne et al., "Chemotropic Guidance of Developing Axons in the Mammalian Central Nervous Systems", Nature 336(6201):775-778 (1988).
Zheng et al., "Chemotaxis of Growth Cone of Xenopus Spinal Neuron in a Gradient of Acetylcholine", Society for Neuroscience Abstracts 19:1481 (1993), abstract.
Zheng et al., "Turing of Nerve Growth Cones Induced by Neurotransmitters", Nature 368:140-144 (1994).
Klar, A. et al., Cell, 69:95-110, 1992.

Affiliated with

Also associated with

Rating

Nucleic acids encoding neural axon outgrowth modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids encoding neural axon outgrowth modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding neural axon outgrowth modulators will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1245089