Nucleic acids encoding myocardial peptides

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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4353201, 4352523, 435348, C07H 2104, C12N 121, C12N 1563

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active

060342307

ABSTRACT:
Disclosed are novel peptides that modulate inflammatory heart disease. Also disclosed are DNA molecules encoding the peptides, and methods of making the peptides.

REFERENCES:
patent: 5252714 (1993-10-01), Harris et al.
Kraft et al., NAR 17:7529-7530, 1989.
Pfordt et al., Genomics 8:194-206, 1990.
Penninger et al., APMIS 105:1-13, 1997.
Compugen GenCore version 4.5 nucleic search of SEQ ID No 24, 1999.
Ausubel et al., eds, Current Protocols in Molecular Biology, Green Publishers Inc. and Wiley and Sons, NY (1994) (Table of Contents Provided).
Ausubel et al., eds., "Metal-Chelate Affinity Chromatography", Current Protocols in Molecular Biology, Section 10.11.B, John Wiley & Sons, NY (1993).
Bodanszky, "Protection by Acylation", Principles of Peptide Synthesis, Springer-Verlag, New York p. 85 et seq. (1984).
Caruthers, "Gene Synthesis Machines: DNA Chemistry and Its Uses", Science, 230: 281-285 (1985).
Danesh et al., "Chronic infections and coronary heart disease: is there a link?", Lancet, 350: 430-436 (1997).
Davis et al., "CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen.sup.1 ", J. Immunol., 160: 870-876 (1998).
Dayhoff et al., Atlas of Protein Sequence and Structure, 5, supp. 3 (1978) (Table of Contents Provided).
de al Maza et al., "Sequence Diversity of the 60-Kilodalton Protein and of a Putative 15-Kilodalton Protein between the Trachoma and Lymphogranuloma Venereum Biovars of Chlamydia trachomatis", Infect. Immun., 59: 1196-1201 (1991).
Engels et al., "Gene Sythesis", Angew. Chem. Intl. Ed., 28: 716-734 (1989).
Francis, "Protein modification and fusion proteins", Focus on Growth Factors, 3: 4-10 (1992).
Genbank Accession No. M76598 May 8, 1992.
Gennaro, ed., Remington's Pharmaceutical Sciences, 18.sup.th Edition, Mack Publishing Company (1990) (Table of Contents Provided).
Houghten et al., "General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids", Proc. Natl. Acad. Sci. USA, 82: 5132 (1985).
Kitts et al., "A Method for Producing Recombinant Baculovirus Expression Vectors at High Frequency", Biotechniques, 14: 810-817 (1993).
Lucklow et al., "Efficient Generation of Infectious Recombinant Baculoviruses by Site-Specific Transposon-Mediated Insertion of Foreign Genes into a Baculovirus Genome Propagated in Escherichia coli", J. Virol., 67: 4566-4578 (1993).
Lucklow, "Baculovirus systems for the expression of human gene products", Curr. Opin. Biotechnol., 4: 546-572 (1993).
Marshall et al, "Oligonucleotide synthesis as a tool in drug discovery research", Drug Discovery Today, 3: 34-42 (1998).
Marston et al., "Solubilization of Protein Aggregates"Meth. Enz., 182: 264-275 (1990).
Merrifield et al., "Solid Phase Peptide Synthesis. I. the Synthesis of a Tetrapeptide", J. Am. Chem. Soc., 85: 2149 (1963).
Messina et al., "Stimulation of In Vitro Murine Lymphocyte proliferation by Bacterial DNA.sup.1 ", J. Immunol, 147: 1759-1764 (1991).
Neu et al., "Cardiac Myosin Induces Myocarditis in Genetically Predisposed Mice.sup.1 ", Immunol., 139: 3630-3636 (1987).
Ossewaarde et al., "Chlamydia pneumoniae is a risk factor for coronary heart disease in symptom-free elderly men, but Helicobacter pylori and cytomegalovirus are not", Epidemiol. and Infect., 120: 93-99 (1998).
Penninger et al., "A Genetic Map of Autoimmune Heart Disease", The Immunologist,4: 131-141 (1996).
Pummerer et al., "Identification of Cardiac Myosin Peptides Capable of Inducing Autoimmune Myocarditis in BALB/c Mice", J. Clin. Invest., 97: 2057-2062 (1996).
Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989) (Table of Contents Provided).
Stein et al., "Physicochemical properties of phosphorothioate oligodeoxynucleotides", Nuc. Acids Res., 16: 3209-3221 (1988).
Stewart and Young, Solid Phase Peptide Synthesis, Pierec Chemical Co., Rockford, IL (1984) (Table of Contents Provided).
Coles et al., NAR 18:6713, 1990.
De la Maza et al., Infect. Immun. 59:1196-1201, 1991.
Clarke et al., Gene:71:5299, 1988.
Watson et al., NAR 18:5299, 1990.
Everett et al., J. Bacteriol. 173:3821-3830, 1991.
Hatt et al., NAR 16: 4053-4067, 1990.
Quinn-Laqeur et al., Genomics 13:176-188, 1992.
Epp et al. Genomics 18:505-509, 1993.
Jaenicke et al., Genomics 8: 194-206, 1990.

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