Nucleic acids encoding microsomal trigyceride transfer protein

Details Nucleic acids encoding microsomal trigyceride transfer protein Nucleic acids encoding microsomal trigyceride transfer protein

1993-09-03

1997-01-21

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352402, 4353201, 935 77, 935 78, 536 231, C12Q 170, C07H 2102, C12N 1579, C12N 510

Patent

active

055958729

ABSTRACT:
Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.

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