Nucleic acids encoding mammalian H-2RIIBP or RXR.sub..beta. and

Details Nucleic acids encoding mammalian H-2RIIBP or RXR.sub..beta. and Nucleic acids encoding mammalian H-2RIIBP or RXR.sub..beta. and

1992-09-28

1995-04-04

Parr, Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 231, 536 243, C07H 2102, C07H 2104, C12Q 168

Patent

active

054039258

ABSTRACT:
The present invention relates generally to the identification and characterization of new genes and proteins. More particularly, the present invention relates to the discovery of novel members of the nuclear hormone receptor superfamily and cDNA clones thereof. The family members are designated as H-2RIIBP (or RXR.sub..beta., retinoid x receptors). These proteins bind selectively only to the native region II sequence of the conserved major histocompatibility complex class I regulatory element (MHC CRE). Sequences homologous to the H-2RIIBP gene are found in the nuclear receptor family including: retinoic acid receptors (RAR), estrogen receptors (ER), thyroid hormone receptors (TR), (COUP-TF), and other RXR isoformes.
This invention also provides for a diagnostic test which determines the nature and progression of a human tumor by measuring the quantity and quality of H-2RIIBP gene dosage or expression.

REFERENCES:
Magnelsdorf, P. et al. Nature 365:224-229 (1990).
Tran, P. et al. MCB 12:4666-4676 (1992).
Hamada et al. (1989) GeneBank deposit printout.
Chambsor et al. (1992) GeneBank Deposit Printout.
Fleischchauer et al. (1992) EMBL deposit printout.
Fleischhauer, K., et al., "Isolation of a Full-Length Clone Encoding a N-Terminally Variant Form of the Human Retinoid X Receptor Beta," Nuc. Acids Res. 20:1801 (1992).
Leid, M., et al., "Purification, Cloning, and RXR Identity of the HeLa Cell Factor with Which RAR or TR Heterodimerizes to Bind Target Sequences Efficiently," Cell 68:377-395 (1992).
Marks, M. S. et al., et al., "H-2RIIBP (RXRBeta) Hetrodimerization Provides a Mechanism for Combinational Diversity in the Regulation of Retinoic Acid and Thyroid Hormone Responsive Genes," EMBO J. 11:1419-1435 (1992).
Hamada, K., et al., "H-2RIIBP, a Member of the Nuclear Hormone Receptor Superfamily That Binds to Both the Regulatory Element of Major Histocompatibility Class I Genes and the Estrogen Response Element," Proc. Natl. Acad. Sci. USA 86:8289-8293 (1989).
Shirayoshi, Y. et al., "Binding of Multiple Nuclear Factors to the 5' Upstream Regulatory Element of the Murine Major Histocompatibility Class I Gene," Mol. Cell Biol. 7:4542-4548 (1987).
Korber, B., et al., "Regulation of Gene Expression by Interferons: Control of H-2 Promoter Responses," Science 239:1302-1306 (1988).
Burke, P. A., "Developmental and Tissue-Specific Expression of Nuclear Proteins That Bind the Regulatory Element of the Major Histocompatibiltiy Complex Class I Gene," J. Exp. Med. 169:1309-1321 (1989).
Yu, V. C., "RXRBeta: A Coregulator That Enchances Binding of Retionic Acid, Thyroid Hormone, and Vitamin D Receptors to Their Cognate Response Elements," Cell 67:1251-1266 (1991).
Marks, M. S., "HR2RIIBP Expressed from a Baculovirus Vector Binds to Multiple Hormone Response Elements," Mol. Endocrinol. 6:219:230 (1992).

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