Nucleic acids encoding kp43 protein and antigenic fragments ther

Details Nucleic acids encoding kp43 protein and antigenic fragments ther Nucleic acids encoding kp43 protein and antigenic fragments ther

1996-05-20

1998-09-22

Kemmerer, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 435 691, 435325, 536 231, 536 235, 536 243, 536 2431, 536 2433, C12N 121, C12N 510, C12N 1512

Patent

active

058112847

ABSTRACT:
The invention provides nucleic acids and polypeptides encoding an NK cell surface antigen from a mammal, as well as antibodies that specifically bind the NK cell surface antigen. Methods of using the nucleic acids, polypeptides, and antibodies are provided, including diagnostic kits comprising one or more of these reagents.

REFERENCES:
Houchins et al. J. Exp. Med. 173;1017-1020 (Apr. 1991).
Bowie et al. Science 247:1306-1310, 1990.
Ngo et al. The Protein Folding Problem and tertiary Structure Prediction, Merz et al, eds, Birkhauser, Boston, 1994.
Reeck et al. Cell 50:667. 1987.
Lewin. Science 237:1570, 1987.
Jose Aramburu, et al., "A Novel Functional Cell Surface Dimer (Kp43) Expressed by Natural Killer Cells and T Cell Receptor-.gamma./.delta. T Lymphocytes: I. Inhibition of the IL-2 Dependent Proliferation by Anti-Kp43 Monoclonal Antibody," J. Immunol., 144:3238-3247, Apr. 15, 1990.
Jose Aramburu, et. al., "A Novel Functional Cell Surface Dimer (Kp43) Expressed by Natural Killer Cells and T Cell Receptor-.gamma./.delta. T Lymphocytes: II. Modulation of Natural Killer Cytotoxicity by Anti-Kp43 Monoclonal Antibody," J. Immunol., 147:714-721, Jul. 15, 1991.
Jose Aramburu, et al., "Stimulation of IL-2-Activated Natural Killer Cells Through the Kp43 Surface Antigen Up-Regulates TNF-.alpha. Production Involving the LFA-1 Integrin," J. Immunol., 151:3420-3429, Oct. 1, 1993.
Maria A. Balboa, et al., "Phospholipase D Activation in Human Natural Killer Cells through the Kp43 and CD16 Surface Antigens Takes Place by Different Mechanisms. Involvement of the Phospholipase D Pathway in Tumor Necrosis Factor .alpha. Synthesis," J. Exp. Med., 176:9-17, Jul.1 992.
Christine A. Biron, et al., "Severe Herpesvirus Infection in an Adolescent Without Natural Killer Cells," N. Engl. J. Med., 320:1731-1735, Jun. 1989.
Kurt Drickamer, "Evolution of Ca.sup.2+ -dependant Animal Lectins," Prog. Nuc. Acids Res., 45:207-232, 1993.
Kazuo Oshimi, "Granular Lymphocyte Proliferative Disorders: Report of 12 Cases and Review of Literature," Leukemia, 2:617-627, Oct. 1988.
Gonzalo Rubio, et al., "A Novel Functional Cell Surface Dimer (kp43) Serves as Accessory Molecule fro the Activation of a Subset of Human .gamma./.delta. T Cells," J. Immunol., 151:1312-1321, Aug. 1, 1993.
Wayne M. Yokoyama, "The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex," Ann. Rev. Immunol., 11:613-635, 1993.

Affiliated with

Also associated with

Rating

Nucleic acids encoding kp43 protein and antigenic fragments ther does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids encoding kp43 protein and antigenic fragments ther, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding kp43 protein and antigenic fragments ther will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1621218