Nucleic acids encoding immunotoxins containing a disulfide-stabi

Details Nucleic acids encoding immunotoxins containing a disulfide-stabi Nucleic acids encoding immunotoxins containing a disulfide-stabi

1999-09-17

2000-06-13

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4242361, 5303873, 5303877, 536 231, A61K 39395, C07K 1600

Patent

active

060746440

ABSTRACT:
This invention provides for nucleic acids encoding immunotoxins comprising a Pseudomonas exotoxin (PE) that does not require proteolytic activation for cytotoxic activity attached to an Fv antibody fragment having a variable heavy chain region bound through at least one disulfide bond to a variable light chain region. The combination of a "disulfide-stabilized" binding agent fused to a PE that does not require proteolytic activation provides an immunotoxin having surprising cytotoxic activity.

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