Nucleic acids encoding immunoglobulin domains

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 235, C07H 2104

Patent

active

060050918

ABSTRACT:
Monoclonal antibodies directed against coagulation factors and their use in inhibiting thrombosis are disclosed.

REFERENCES:
Bajaj et al., "A Monoclonal Antibody to Factor IX That Inhibits the Factror VIII:Ca Potentiation of Factor X Activation", J. Biol. Chem., vol. 260, No. 21, pp. 11574-11580 (1985).
Bajaj et al., "Antibody-Probed Conformational Transistions in the Protease Domain of Human Factor IX Upon Calcuim Binding and Zymogen Activation: Putative High-Affinity Ca.sup.2+ -Binding Site in the Protease Domain", Proc. Natl. Acad. Sci, USA, vol. 89, pp. 152-156 (1992).
Cheung et al., "Localization of a Calcuim-Dependent Epitope to the Amino Terminal Region of the GLA Domain of Human Factor IX", Thrombosis Research, vol. 81, No. 1, pp. 65-73 (1996).
Church et al., "An Inhibitory Monoclonal Antibody to Factor X that Blocks Prothombin Activation but not Prothrombinase Enzyme Assembly", Blood, vol. 72, No. 6 (Dec.), pp. 1911-1921 (1988).
Donath et al., "Kinetics of Factor VIII Light-Chain Cleavage by Thrombin and Factor Xa", Eur. J. Biochem., vol. 240, 365-372 (1996).
Frazier et al., "Mapping of Monoclonal Antibodies to Human Factor IX", Blood, vol. 74, No. 3, pp. 971-977 (1989).
Fulcher et al., "Localization of Human Factor FVIII Inhibitor Epitopes of Two Polypeptide Fragments", Proc. Natl. Acad. Sci. USA, vol. 82, pp. 7728-7732 (1985).
Healey et al., "Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII", J. Biol. Chem, vol. 270, No. 24, pp. 14505-14509 (1995).
Hoffman et al., "Factors IXa and Xa Play Distinct Roles in Tissue Factor-Dependent Initiation of Coagulation", Blood, vol. 86, No. 5, pp. 1794-1801 (1995).
L. Hoyer and D. Scandella, "Factor VIII Inhibitors: Structure and Function in Autoantibody and Hemophilia A Patients", Seminars in Hematology, vol. 31, No. 2, Suppl. 4, pp. 1-5 (1994).
Jenny et al., "Immunochemical Techniques for Studying Coagulation Proteins"Methods in Enzymology, vol. 222, pp. 400-416 (1993).
Larson et al., "Structural Integrity of the .gamma.-Carboxyglutamic Acid Domain of Human Blood Coagulation Factor IXa is Required for Its Binding to Cofactor VIIIa", J. Biol. Chem., vol. 271, No. 7, pp. 3869-3876 (1996).
Leyte et al., "Inhibition of Human Coagulation Factor VIII by Monoclonal Antibodies", J. Biochem., vol. 263, pp. 187-194 (1989).
Lollar et al., "Inhibition of Human Factor Villa by Anti-A2 Subunit Antibodies", J. Clin. Invest., vol. 93, pp. 2497-2504 (1994).
J. Loscalzo and A. Schafer, "Factor VIII and Other Coagulation Factor Inhibitors", Thrombosis and Hemorrhage, Chapter 37, pp. 729-747 (1994).
Lubin et al., "Elimination of a Major Inhibitor Epitope in Factor VIII", J. Biol. Chem., vol. 269, No. 12, pp. 8639-8641 (1994).
Ouelette et al., "Neutralization of Factor X Activity by Factor X-Specific Monoclonal Antibodies", Blood Coagulation and Fibrinolysis, vol. 3, pp. 563-574 (1992).
Saenko et al., "Slowed Release of Thrombin-Cleaved Factor VIII from von Willebrand Factor by a Monoclonal and a Human Antibody Is a Novel Mechanism for Factor VIII Inhibition", J. Biol. Chem., vol. 271, No. 44, pp. 27424-27431 (1996).
D. Scandella, "Human Antibodies Which Inactivate Factor VIII: Their Epitope Specificity and Biochemical and Functional Characteristics", International Journal of Pediatric Hematology/Oncology, vol. 1, pp. 437-447 (1994).
D. Scandella, "Human Anti-Factor VIII Antibodies: Epitope Localization and Inhibitory Function", Vox Sangunis, vol. 70 (suppl 1), pp. 9-14 (1996).
Sinha et al., "Functional Characterization of Human Blood Coagulation Factor XIa USing Hybridoma Antibodies", J. of Biol. Chem., vol. 260, No. 19, pp. 10714-10719 (1985).
Sohngen et al., "Acquired Factor VIII Inhibitors in Nonhibitors in Nonhemophilic Patients", Ann Hematol, vol. 74, pp. 89-93 (1997).
Sugahara et al., "Isolation and Characterization of Canine Factor IX", Thrombosis and Haemostasis, vol. 75(3), pp. 450-455 (1996).
Tiarks et al., "Factor VIII Epitopes Recognized with Inhibitory Monoclonal Antibodies", Acta Haematol, vol. 83, pp. 69-75 (1990).
Abstracts, "Thrombosis and Haemostasis", J. International Society on Thrombosis and Haemostasis, vol. 69(6), p. 1239, Abstract 2485 (1993).
Bessos et al., "The Characterization of a Panel of Monoclonal Antibodies to Human Coagulation Factor IX", Thrombosis Research, vol. 40, pp. 863-867 (1985).
Lenting et al., "A Novel Antithrombotic Strategy Based on Inhibitors of Factor VIII-factor IX Complex Assemply", Thrombosis and Hemostasis, June Supplement, p. 689 (1997).
Lenting et al., "The Sequence Glu.sup.1811 -Lys.sup.1818 of Human Blood Coagulation Factor VIII Comprises a Binding Site for Activated Factor IX", The Journal of Biological Chemistry, vol. 271, No. 4, pp. 1935-1940 (1996).
Lenting et al., "Identification of Binding Site for Blood Coagulation Factor IXa on the Light Chain of Human Factor VIII", The Journal of Biological Chemistry, vol. 269, No. 10, pp. 7150-7155 (1994).
Biemond et al., "Complete Inhibition of Endotoxin-Induced Coagulation Activation in Chimpanzees with a Monoclonal Fab Fragment against Factor VII/VIIa", Thrombosis and Haemostasis, vol. 73, No. 1, pp. 223-230 (1995).
F. Desposito and Y. Arkel, "Inhibitors of Coagulation in Children" Critical Reviews in Oncology/Hematology, vol. 7, No. 1, pp. 53-69 (1987).
Griffin et al., "The Production and Characterisation of a Panel of Ten Murine Monoclonal Antibodies to Human Procoagulant Factor VIII", Thrombosis and Haemostasis, vol. 55 (1), pp. 40-46 (1986).
S. Morrison, "In Vitro Antibodies: Strategies for Production and Application", Annu. Rev. Immunol. vol. 10, pp. 239-265 (1992).
Warrier et al., "Safety of High Doses if a Monoclonal Antibody-Purified Factor IX Concentrate", American Journal of Hematology, vol. 49, pp. 92-94 (1995).
Stryer, Biochemistry, W.H Freemanual Compnay, San Francisco, 1981 pp. 512-513.
Kasai et al J. Immunol Methods 155(1):77-89, 1992.
Fang et al. J. Exp. Med. 179(5): 1445-1456, 1994.
Silberstein et al J. Exp. Med 169(5): 1631-1643, 1989.
Paschal et al. J. Clin Invest 86(4): 1320-1328, 1990.
Roark et al. J. Exp. Med. 181(3):1157-1167, 1995.
Caton et al.. J. Exp. Med. 174(3):613-624, 1991.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acids encoding immunoglobulin domains does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids encoding immunoglobulin domains, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding immunoglobulin domains will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-506411

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.