Nucleic acids encoding human TNF-α convertase

Details Nucleic acids encoding human TNF-α convertase Nucleic acids encoding human TNF-α convertase

2008-04-15

2008-04-15

Blanchard, David J. (Department: 1643)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S183000, C435S320100, C435S325000, C424S146100, C530S350000, C530S388260

Reexamination Certificate

active

07358352

ABSTRACT:
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-α. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-α convertases, and for identifying nucleic acids encoding such convertases.

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