Nucleic acids encoding human monoclonal antibodies to CTLA-4

Details Nucleic acids encoding human monoclonal antibodies to CTLA-4 Nucleic acids encoding human monoclonal antibodies to CTLA-4

2005-05-12

2008-08-12

Ouspenski, Ilia (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S023500, C435S069100, C435S252300, C435S320100, C435S455000

Reexamination Certificate

active

07411057

ABSTRACT:
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

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