Nucleic acids encoding human metabotropic glutamate receptors

Details Nucleic acids encoding human metabotropic glutamate receptors Nucleic acids encoding human metabotropic glutamate receptors

1993-06-04

1996-05-28

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4352401, 4353201, C07H 2102, C12N 510, C12N 1579, C12N 1585

Patent

active

055212972

ABSTRACT:
In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.

REFERENCES:
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Daggett et al., "Cloning and Functional Expression of the Human Metabotropic mGluR5 Receptor" Abstract: 1993 Annual Meeting, Washington, DC, Nov. 7-12, 1993.
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