Nucleic acids encoding human calcium channel and methods of...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S071100, C435S071200, C435S252300, C435S254110, C435S069100, C435S325000, C435S354000, C435S358000, C435S320100, C435S471000, C536S023500

Reexamination Certificate

active

07063950

ABSTRACT:
Isolated DNA encoding each of human calcium channel α1-, α2-, β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

REFERENCES:
patent: 4788135 (1988-11-01), Davis et al.
patent: 4912202 (1990-03-01), Campbell et al.
patent: 4954436 (1990-09-01), Froehner et al.
patent: 5024939 (1991-06-01), Gorman
patent: 5051403 (1991-09-01), Miljanich et al.
patent: 5189020 (1993-02-01), Miljanich et al.
patent: 5264371 (1993-11-01), Miljanich et al.
patent: 5424218 (1995-06-01), Miljanich et al.
patent: 2085502 (1993-02-01), None
patent: 0507170 (1992-03-01), None
patent: 0556651 (1993-04-01), None
patent: 8907608 (1989-08-01), None
patent: 8909834 (1989-10-01), None
patent: 9113077 (1991-09-01), None
patent: 9202639 (1992-02-01), None
patent: 9308469 (1993-04-01), None
patent: 93/14098 (1993-07-01), None
patent: 9402511 (1994-02-01), None
patent: 9504144 (1995-02-01), None
Adams, M. D., et al. (Jun. 30, 1993) GenBank Record No. T05783, “EST03672” [attached to Office action] —(Jun. 30, 1993) Gen Bank Record No. T06059, “EST03948” [attached to action].
Powers, et al., “Assignment of the human gene for the α1subunit of the cardiac DHP-sensitive Ca2+channel (CCHL1A1) to Chromosome 12p12-pter,”Genomics, 10: 835-839 (1991).
Kim, et al., “IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels,”Science, 239: 405-408 (1988).
Claudio, et al., “Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts,”Science, 238: 1688-1694 (1987).
Tanabe, et al., “Primary structure of the receptor for calcium channel blockers from skeletal muscle,”Nature, 328: 313-318 (1987).
Nakayama, et al., “Purification of a putative Ca2+channel protein from rabbit skeletal muscle,”J.Biol.Chem., 262: 6572-6576 (1987).
Vaghy, et al., “Identification of a novel 1,4-dihydropyridine-and phenylalkylamine-binding polypeptide in calcium channel preparations,”J.Biol.Chem., 262(29): 14337-14342 (1987).
Leung, et al., “Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+channel from rabbit skeletal muscle,”J.Biol.Chem., 262(17): 7943-7946 (1987).
Sharp, et al., “Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor,”J.Biol.Chem., 62(25): 12309-12315 (1987).
Takahashi, et al., “Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle,”Proc.Natl.Acad.Sci.(USA), 84: 5478-5482 (1987).
Morton et al. “Monoclonal antibody identifies a 200-kDA subunit of the dihydropyri-dine-sensitive calcium channel,”J.Biol.Chem., 262(25): 11904-11907 (1987).
Barhanin, et al., “The calcium channel antagonists receptor from rabbit skeletal muscle: reconstitution after purification and subunit characterization,”Eur.J.Biochem., 164: 525-531 (1987).
Sieber, et al., “The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel,”Eur.J.Biochem., 167: 117-122 (1987).
Lang, et al., “The effect of myasthenic syndrome antibody on presynaptic calcium channels in the mouse,”J.Physiol., 390: 257-270 (1987).
Curran and Morgan, “Barium modules c-fos expression and post-translational modification,”Proc.Natl.Acad.Sci., 83: 3521-8524 (1986).
Fisch, et al., “c-fos sequences necessary for basal expression and induction by epidermal growth factor, 12-0-tetradecanoyl phorbol-13-acetate, and the calcium inophore,”Mol.Cell.Biol., 7(10): 3490-3502 (1987).
Noda, et al., “Existence of distinct sodium channel messenger RNAs in rat brain,”Nature, 320: 188-192 (1986).
Noda, et al., “Expression of functional sodium channels from cloned cDNA,”Nature, 322: 826-828 (1986).
Mierendorf, et al., “Gene isolation by screening kgtll libraries with antibodies,”Methods in Enz., 152: 458-469 (1986).
Gustin, et al., “Ion channels in yeast,”Science, 233: 1195-1197 (1986).
Striessnig, et al., “Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel,”FEBS Letters, 212(2):247-253 (1987).
Froehner, “New insights into the molecular structure of the dihydropyridine-sensitive calcium channel,”TINS, 11(3): 90-92 (1988).
Catterall, et al., “Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle,”J.Biol.Chem., 263(8): 3535-3538 (1988).
Curtis, et al., “Purification fo the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules,”Biochemistry, 23(10): 2113-2118 (1984).
Borsotto, et al., “The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+channel,”J.Biol.Chem., 260(26): 14255-14263 (1985).
Cooper, et al., “Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac from cardiac tissue,”J.Biol.Chem., 262(2): 509-512 (1987).
Wood, “Gene cloning based on long oligonucleotide probes,”Methods in Enzymology, 152: 443-447 (1987).
Schmid, et al., “Immunochemical analysis of subunit structure of 1,4-dihydropyridine receptors associated with voltage-dependent Ca2+channels in skeletal, cardiac, and smooth muscles,”Biochemistry, 25: 3492-3495 (1986).
Mishina, et al., “Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis,”Nature, 313: 364-369 (1985).
Hamill, et al., “Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches,”Pfluger Archiv.European Journal of Physiology, 391: 85-100 (1981).
Hess, et al., “Different modes of Ca channel gating behavior favored by dihydropyridine Ca agonist and antagonists,”Nature, 311: 538-544 (1984).
Leung, et al., “Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle,”J. of Biol.Chem., 263(2): 994-1001 (1988).
Imagawa, et al., “Phosphorylation of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+channel by an intrinsic protein kinase in isolated triads from rabbit skeletal muscle,”J. of Biol.Chem., 262(17): 8333-8339 (1987).
Miller, “Multiple calcium channels and neuronal function,”Science, 235: 46-52 (1987).
Kozak, “An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs,”Nucleic Acids Research, 15(20): 8125-8148 (1987).
von Heijne, “Signal sequences: the limits of variation,”Jour. of Mol.Biol., 184: 99-105 (1985).
Hubbard, et al., “Synthesis and processing of asparagine-linked oligosaccharides1,2,”Ann.Rev.Biochem., 50: 555-583 (1981).
Feramisco, et al., “Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase,”Journal of Biological Chemistry, 255(9): 4240-4245 (1980).
Takahashi, et al., “Identification of an α subunit of dihydropyridine-sensitive brain calcium channels,”Science, 236: 88-91 (1987).
Hofmann, et al., “Regulation of the L-type calcium channel,”TINS, 8: 393-398 (1987).
Curtis, et al., “Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules,”Biochemistry, 25: 3077-3083 (1986).
Smith, et al., “Calcium channel activity in a purified dihydropyridine-receptor preparation of skeletal muscle,”Biochemistry, 26: 7182-7188 (1987).
Meshi, et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acids encoding human calcium channel and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids encoding human calcium channel and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding human calcium channel and methods of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3683176

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.