Nucleic acids encoding human astrovirus serotype 2

Details Nucleic acids encoding human astrovirus serotype 2 Nucleic acids encoding human astrovirus serotype 2

1993-05-12

1997-04-29

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, C07H 2102, C07H 2104

Patent

active

056250495

ABSTRACT:
The present invention provides a nucleic acid encoding human Astrovirus serotype 2, or a unique fragment thereof. The sequence, a genomic RNA of human astrovirus serotype 2 contains 6,797 nucleotides, and is organized into three open reading frames. Also provided are purified antigenic polypeptide fragments encoded by the nucleic acid encoding human Astrovirus serotype 2, or unique portions thereof. The present invention also provides a monoclonal antibody specific for human astrovirus serotype 2 and isolated nucleic acids capable of selectively hybridizing with the nucleic acid of serotype 2, including methods for detecting the presence of serotype 2 utilizing these products.

REFERENCES:
Sommer et al (Nucleic Acid Res 17:6749) 1989.
Embase No. 83104244 J. Hyg. 89/3: 539-540 (1982).
Wyn-Jones et al., Wat. Sci. Tech. 24: 285-290 (1991) "Growth of Clinical isolates of Astrovirus in a cell . . . ".
Young et al., P.N.A.S. 80: 1194-1198 (1983) "Efficient isolation of genes . . . ".
Herring et al., J. Gen. Virol. 53: 47-55 (1981) "Purification and characterization of Ovine . . . ".
Kurtz et al., Lancet 2:1405 (1984) "Human Astrovirus Serotypes".
Matsui et al., J. Virol 67:1712-1715 (1993) "Cloning and characterization of human astrovirus . . . ".
Willcocks et al., Epidermiol. Infect 107:405-410 (1991) "A dot-blot hybridization procedure . . . ".
Willcocks et al. Arch. Virol. 124:279-289 (1992) "The 3' terminal sequence of a human astrovirus".
Suzanne M. Matsui et al., "Cloning and Characterization of Human Astrovirus Immunoreactive Epitopes," Journal of Virology, 67(3):1712-1715 (Mar. 1993).
M.E. Major et al., "3' Terminal Nucleotide Sequence of Human Astrovirus Type 1 and Routine Detection of Astrovirus Nucleic Acid and Antigens," Journal of Virological Methods, 39:217-225 (1992).
M.M. Willcocks et al., "The 3' Terminal Sequence of a Human Astrovirus," Arch. Virol., 124:279-289 (1992).
Stephan S. Monroe et al., "Temporal Synthesis Proteins and RNAs During Human Astrovirus Infection of Cultured Cells," Journal of Virology, 65(2):641-648 (Feb. 1991).
Stephan S. Monroe et al., "Human Astrovirus Serotype 2: cDNA Sequencing and Use of PCR for Detection in Clinical Specimens," Third International Symposium on Positive Strand RNA Viruses, Clearwater, Florida, Sep. 19-24, 1992.

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