Nucleic acids encoding fragments of hematopoietic stem cell rece

Details Nucleic acids encoding fragments of hematopoietic stem cell rece Nucleic acids encoding fragments of hematopoietic stem cell rece

1992-11-19

1993-12-14

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4353201, 530350, 530403, C07H 2100

Patent

active

052704580

ABSTRACT:
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.

REFERENCES:
patent: 5185438 (1993-02-01), Lemischka
W. Matthews et al. Cell 65:1143-1152 Jun. 28, 1991.
O. Rosnet et al. Genomies 9:380-5 Feb. 1991.
O. Rosnet et al. Oncogene 6:1641-50 Sep. 1991.
C. T. Jordan et al. Cell 61:953-63 Jun. 15, 1990.

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