Nucleic acids encoding endotheliases, endotheliases and uses...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S004000, C435S006120, C435S069100, C435S183000, C536S023200

Reexamination Certificate

active

09717473

ABSTRACT:
Provided herein are endotheliases and portions, particularly, the protease domains, and nucleic acids that encode the endotheliases. The endotheliases are transmembrane proteases expressed in endothelial cells. The nucleic acids and encoded proteins and protease domain portions thereof are used in a variety of prognostic, diagnostic, therapeutic and screening methods, including methods for screening for compounds that modulate angiogenesis.

REFERENCES:
patent: 3536809 (1970-10-01), Applezweig
patent: 3598123 (1971-08-01), Zaffaroni
patent: 3630200 (1971-12-01), Higuchi
patent: 3843443 (1974-10-01), Fishman
patent: 3846770 (1974-11-01), Theeuwes et al.
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 3940475 (1976-02-01), Gross
patent: 4006117 (1977-02-01), Merrifield et al.
patent: 4008719 (1977-02-01), Theeuwes et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4496689 (1985-01-01), Mitra
patent: 4507230 (1985-03-01), Tam et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4640835 (1987-02-01), Shimizu et al.
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 4687610 (1987-08-01), Vassilatos
patent: 4769027 (1988-09-01), Baker et al.
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 4908405 (1990-03-01), Bayer et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4952496 (1990-08-01), Studier et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 5059595 (1991-10-01), Le Grazie
patent: 5073543 (1991-12-01), Marshall et al.
patent: 5120548 (1992-06-01), McClelland et al.
patent: 5215899 (1993-06-01), Dattagupta
patent: 5225539 (1993-07-01), Winter
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5292814 (1994-03-01), Bayer et al.
patent: 5346823 (1994-09-01), Estell et al.
patent: 5354566 (1994-10-01), Addesso et al.
patent: 5389449 (1995-02-01), Afeyan et al.
patent: 5436128 (1995-07-01), Harpold et al.
patent: 5482848 (1996-01-01), Dickson et al.
patent: 5589154 (1996-12-01), Anderson
patent: 5591767 (1997-01-01), Mohr et al.
patent: 5593990 (1997-01-01), D'Amato
patent: 5612474 (1997-03-01), Patel
patent: 5629327 (1997-05-01), D'Amato
patent: 5639476 (1997-06-01), Oshlack et al.
patent: 5674533 (1997-10-01), Santus et al.
patent: 5712291 (1998-01-01), D'Amato
patent: 5733566 (1998-03-01), Lewis
patent: 5792616 (1998-08-01), Persico et al.
patent: 5804410 (1998-09-01), Yamaoka et al.
patent: 5902723 (1999-05-01), Dower et al.
patent: 5925525 (1999-07-01), Fodor et al.
patent: 5972616 (1999-10-01), O'Brien et al.
patent: 6121238 (2000-09-01), Dower et al.
patent: 6294663 (2001-09-01), O'Brien et al.
patent: 37857 (2002-03-01), Semple et al.
patent: 6365391 (2002-04-01), Webster et al.
patent: 107266 (2002-08-01), Lim-Wilby et al.
patent: 160962 (2002-10-01), Saksena et al.
patent: 8372 (2003-01-01), Madison et al.
patent: 2002/0019006 (2002-02-01), Yuan et al.
patent: 2002/0064856 (2002-05-01), Plowman et al.
patent: 2002/0119130 (2002-08-01), Eaton et al.
patent: 2003/0073129 (2003-04-01), Baker et al.
patent: 2003/0175938 (2003-09-01), Shi et al.
patent: 2003/0232349 (2003-12-01), Delegeane et al.
patent: 200010689 (2000-09-01), None
patent: 0257352 (1988-03-01), None
patent: 0613683 (1994-09-01), None
patent: 0613683 (1994-09-01), None
patent: 8809810 (1988-12-01), None
patent: 8910134 (1989-11-01), None
patent: 9011364 (1990-10-01), None
patent: 9206180 (1992-04-01), None
patent: 9220316 (1992-11-01), None
patent: 9222635 (1992-12-01), None
patent: 9314188 (1993-07-01), None
patent: 9320221 (1993-10-01), None
patent: 9325221 (1993-12-01), None
patent: 9408598 (1994-04-01), None
patent: 9417784 (1994-08-01), None
patent: 9511755 (1995-05-01), None
patent: 9523222 (1995-08-01), None
patent: 9534326 (1995-12-01), None
patent: 8603840 (1996-07-01), None
patent: 9630353 (1996-10-01), None
patent: 9721690 (1997-06-01), None
patent: 9917790 (1999-04-01), None
patent: 9936550 (1999-07-01), None
patent: 9942120 (1999-08-01), None
patent: 9946281 (1999-09-01), None
patent: 0012708 (2000-03-01), None
patent: 0050061 (2000-08-01), None
patent: 0052044 (2000-09-01), None
patent: 0053232 (2000-09-01), None
patent: 0053756 (2000-09-01), None
patent: 0055124 (2000-09-01), None
patent: 0068247 (2000-11-01), None
patent: 0078961 (2000-12-01), None
patent: 0104141 (2001-01-01), None
patent: 0127624 (2001-04-01), None
patent: 0136351 (2001-05-01), None
patent: 0136604 (2001-05-01), None
patent: 0136645 (2001-05-01), None
patent: 0146407 (2001-06-01), None
patent: 0149864 (2001-07-01), None
patent: 0154477 (2001-08-01), None
patent: 0155441 (2001-08-01), None
patent: 0157194 (2001-08-01), None
patent: 0168848 (2001-09-01), None
patent: 0175067 (2001-10-01), None
patent: 0200860 (2002-01-01), None
patent: 0206453 (2002-01-01), None
patent: 0208251 (2002-01-01), None
patent: 02008187 (2002-01-01), None
patent: 02095007 (2002-02-01), None
patent: 0220475 (2002-03-01), None
patent: 0226947 (2002-04-01), None
patent: 02048097 (2002-06-01), None
patent: 02072786 (2002-09-01), None
patent: 02077263 (2002-10-01), None
patent: 02077267 (2002-10-01), None
patent: 02092841 (2002-11-01), None
patent: 03004681 (2003-01-01), None
Yamaoka et al. J. Biol. Chem., 1998, vol. 273:11895-11901.
Sequence alignment for Shi et al.
Sequence alignment for Baker et al.
Sequence alignment for Eaton et al.
Sequence alignment for Xiao et al. (DNA).
Sequence alignment for Xiao et al. (polypeptide).
Sequence alignment for Ni et al.
Derwent#007409639, WPI Acc. No. 1988-043574/198807, for European Patent Application, EP 257352, “Determining free portion of e.g. thyroxine in presence of binder—by reaction with antibody which does not effect bound-unbound equilibium, then reacting cross reactive tracer with antibody”.
Harris et al., “Rapid and general profiling of protease specificity by using combinatorial flurogenic substrate libraries,”PNAS 97: 7754-7759 (2000).
Liu et al., “Eradication of large colon tumor xenografts by targeted delivery of maytansinoids”,Proc Natl Acad Sci USA, 93:8618-8623 (1996).
Pastan et al., “Recombinant Toxins for Cancer Treatment”,Science, 254:1173-1177; (1991).
Schmidt, M. and W. Wels, “Targeted inhibition of tumour cell growth by a bispecific single-chian toxin containing an antibody domain and TGFα”,British Journal of Cancer, 74:853-862 (1996).
Abraham et al., “Immunochemical Identification of the Serine Protease Inhibitor α1-Antichymotrypsin in the Brain Amyloid Deposits of Alzheimer's Disease”,Cell, 52:487-501; (1988).
Alam et al., “Reporter Genes: Application to the Study of Mammalian Gene Transcription”,Anal. Biochem., 188:245-254; (1990).
Alonso et al., “Effects of synthetic urokinase inhibitors on local invasion and metastasis in a murine mammary tumor model”,Breast Cancer Res. Treat., 40:209-223; (1996).
Appel et al., “TheDrosophilaStubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis”,Proc. Natl. Acad. Sci. U.S.A., 90:4937-4941; (1993).
Avery et al., “Systemic Amiloride Inhibits Experimentally Induced Neovascularization”,Arch. Ophthalmol., 108:1474-1476; (1990).
Bains et al., “Effects of LEX032, a novel recombinant serine protease inhibitor, onNG-nitro-L-arginine methyl ester induced leukocyte-endothelial cell”,Eur. J. Pharmacol., 356:67-72; (1998).
Baker et al., “A Scintillation Proximity Assay for UDP-GaINAc:Polypeptide,N-Acetylgalactosaminyltransferase”,Anal. Biochem., 239:20-24; (1996).
Batra et al., “Insertion of Constant Region Domains of Human IgG1Into CD4-PE40 Increases Its Plasma Half-life”,Molecular Immunol., 30(4):379-386; (1993).
Baum et al., “Development of a Scintillation Proximity Assay for Human Cytomegalovirus Protease Using33Phosphorous”,Anal. Biochem., 237:129-134; (1996).
Beck et al., “Identification of Efficiently Cleaved Substrates for HIV-1 Protease Using a Phage Display Library and Use in Inhibitor Developm

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acids encoding endotheliases, endotheliases and uses... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids encoding endotheliases, endotheliases and uses..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding endotheliases, endotheliases and uses... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3885521

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.