Nucleic acids encoding dog gastric lipase and their use for the

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

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4352523, 4353201, 536 232, C12N 920, C12N 121, C12N 1563, C07H 2104

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active

058077260

ABSTRACT:
The present invention relates to dog gastric lipase as obtained by genetic engineering as well as to the nucleotide sequence encoding this recombinant DGL. It also relates to the use of this recombinant DGL for the production of pharmaceutical compositions intended especially for the treatment of pathologies linked to the insufficiency, or even the absence, of secretion of lipases in the body of an individual.

REFERENCES:
patent: 5075231 (1991-12-01), Moreau et al.
European Journal of Biochemistry, vol. 202, 1991, pp. 75-83, Carriere F. et al., "Purifiation and biochemical characterization of dog gastric lipase".
Biochemica et Biophysica acta, vol. 1083, No. 1, 1991, pp. 109-119, S. J. Iverson et al., "Milk lipid digestion in the neonatal dog; the combined actions of gastric and bile salt stimulated lipases".

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