Nucleic acids encoding D-type cyclins and hybridization probes

Details Nucleic acids encoding D-type cyclins and hybridization probes Nucleic acids encoding D-type cyclins and hybridization probes

1995-06-05

1999-02-09

Houtteman, Scott W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4352523, 4353201, 435363, C12N 1511

Patent

active

058696407

ABSTRACT:
The present invention relates to a novel class of cyclins, referred to as D-type cyclins, of mammalian origin, particularly human origin, DNA and RNA encoding the novel cyclins, and a method of identifying other D-type and non-D type cyclins. Also disclosed are a method of detecting an increased level of a D-type cyclin and a method of inhibiting cell division by interfering with formation of the protein kinase-D type cyclin complex essential for cell cycle start.

REFERENCES:
Motokura et al., Nature, 350:512-515, Apr. 11, 1991.

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