Nucleic acids encoding cytokine-like proteins that promote...

Details Nucleic acids encoding cytokine-like proteins that promote... Nucleic acids encoding cytokine-like proteins that promote...

2007-08-07

2007-08-07

Spector, Lorraine M. (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S069520, C435S325000, C435S252300, C435S320100, C536S023500

Reexamination Certificate

active

10440066

ABSTRACT:
A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing printers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of the thus-isolated cDNA and analysis of its structure revealed that the cDNA has typical characteristics of a factor belonging to the IL-6/G-CSF/MGF family. It is also found out that the culture supernatant of said sequence-transfected CHO cells shows a proliferation supporting activity towards bone marrow cells in the coexistence of kit ligand.

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