Nucleic acids encoding costimulatory molecule B7-4

Details Nucleic acids encoding costimulatory molecule B7-4 Nucleic acids encoding costimulatory molecule B7-4

2005-08-30

2005-08-30

Gambel, Phillip (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S023400, C435S069100, C435S455000, C435S252300, C435S320100, C435S471000, C435S326000

Reexamination Certificate

active

06936704

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 2002/0055139 (2002-05-01), Holtzman et al.
patent: WO 95/03408 (1995-02-01), None
patent: WO 01/14557 (2001-03-01), None
patent: WO 01/39722 (2001-06-01), None
Code #'s 27-7975-01, 27-7609-01,27-7610-01, 27-7856-01, 27-7857-01, or 27-7858-01 in Pharmacia Biotech “BioDirectory” 1997 catalog, p. 44, Pharmacia Biotech Inc, 800 Centennial Ave., Piscataway, New Jersey 08855-1327.
Metzler et al. Nature Structural Biol. 1997; 4:527-531.
Stedman's Medical Dictionary, 24th Edition, 1982 Williams & Wilkins, Baltimore, MD, p. 42.
Voet et al. In Biochemistry. John Wiley & Sons. 1990, vol. 1, pp. 126-128, and p. 230.
Attwood Science 290(5491):471-473, Oct. 27, 2000.
Skolnick et al. Trends in Biotech., 18(1):34-39, 2000.
Coyle et al. Nature Immunol. 2:203-209 2001.
Dong, Haidong et al., GenBank Acession No. AF177937, Jan. 19, 2000.
Dong, Haidong et al., “B7-H1, a third member, a third of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.”Natural Medicine, (1999), vol. 5, No. 12, pp.: 1365-1369.
Freeman, Gordon, J. et al., “Engagement of the PD-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation.” Journal Experimental Medicine, (1998), vol. 192 No. 7, pp.: 1027-1034.
Henry, Joelle et al., “Structure and evolution of the extended B7 family.”Immunology Today, (1999), vol. 20, No. 6, pp.: 285-288.
GenBank Acession No. AA292201, Apr. 21, 1997.
GenBank Acession No. AA399416, Apr. 29, 1997.
GenBank Acession No. Q13410, Nov. 1, 1997.

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