Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2008-03-04
2008-03-04
Robinson, Hope (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S006120, C435S320100, C435S252000, C435S325000, C435S007100, C530S350000
Reexamination Certificate
active
07338784
ABSTRACT:
Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins are further characterized in that they are either obtained from non-bioluminescent Cnidarian, e.g., Anthozoan, species or are obtained from non-Pennatulacean (sea pen) species. Specific proteins of interest include proteins obtained from the following specific Anthozoan species:Anemonia majano(NFP-1),Clavulariasp. (NFP-2),Zoanthussp. (NFP-3 & NFP-4),Discosoma striata(NFP-5),Discosomasp. “red”(NFP-6),Anemonia sulcata(NFP-7),Discosomasp. “green” (NFP-8), andDiscosomasp.“magenta” (NFP-9). Also of interest are proteins that are substantially similar to, or mutants of, the above specific proteins. Also provided are fragments of the nucleic acids and the peptides encoded thereby, as well as antibodies to the subject proteins and transgenic cells and organisms. The subject protein and nucleic acid compositions find use in a variety of different applications. Finally, kits for use in such applications, e.g., that include the subject nucleic acid compositions, are provided.
REFERENCES:
patent: 5491084 (1996-02-01), Chalfie et al.
patent: 5874304 (1999-02-01), Zolotukhin et al.
patent: 5919445 (1999-07-01), Chao
patent: 5958713 (1999-09-01), Thastrup et al.
patent: 5968738 (1999-10-01), Anderson et al.
patent: 5968750 (1999-10-01), Zolotukhin et al.
patent: 5976796 (1999-11-01), Szalay et al.
patent: 5985577 (1999-11-01), Bulinski
patent: 6020192 (2000-02-01), Muzyczka et al.
patent: 6066476 (2000-05-01), Tsien et al.
patent: 6342379 (2002-01-01), Tsien et al.
patent: 197 18 (1997-05-01), None
patent: WO 99/49019 (1999-09-01), None
patent: WO 00/34318 (1999-12-01), None
patent: WO 00/34319 (1999-12-01), None
patent: WO 00/34320 (1999-12-01), None
patent: WO 00/34321 (1999-12-01), None
patent: WO 00/34322 (1999-12-01), None
patent: WO 00/34323 (1999-12-01), None
patent: WO 00/34324 (1999-12-01), None
patent: WO 00/34325 (1999-12-01), None
patent: WO 00/34326 (1999-12-01), None
patent: WO 00/34526 (1999-12-01), None
patent: WO 00/46233 (2000-08-01), None
patent: WO 01/27150 (2000-10-01), None
patent: WO 01/32688 (2001-05-01), None
patent: WO 01/34824 (2001-05-01), None
Anderluh et al., Biochemical and Biophysical Research Communications (1996) 220:437-442.
Baird et al. “Biochemistry, Mutagenesis and Oligomerization of DsRed, a Red Fluorescent Protein from Coral,” PNAS (2000) 97(22):11984-11989.
Dove et al., Biological Bulletin (1995) 189:288-297.
Fradkov et al., FEBS Lett. (2000) 479(3):127-30.
Gurskaya et al., FEBS Lett., (2001) 507(1):16-20.
Gurskaya et al., BMC Biochem. (2001) 2:6.
Haas et al. “Codon Usage Limitation in the Expression of HIV-1 Envelope Glycoprotein,” Current Biology (1996) 6(3):315-324.
Heim et al. PNAS (1994) 91:12501-04.
Lukyanov, K., et al (2000) J Biol Chemistry 275(34):25879-25882.
Macek et al., Eur. J. Biochem. (1995) 234:329-335.
Martynov et al., J Biol Chem. (2001) 276:21012-6.
Matz, M.V., et al. (1999)Nature Biotechnol.17:969-973.
Terskikh et al., Science (2000) 290:1585-8.
Tsien, Annual Rev. of Biochemistry (1998) 67:509-544.
Tsien, Nat. Biotech. (1999) 17:956-957.
Wall et al. “The Structural Basis for Red Fluorescence in the Tetrameric GFP Homolog DsRed,” Nature Structural Biology (2000) 7(12):1133-1138.
Ward et al., J. Biol. Chem. (1979) 254:781-788.
Wells, Biochemistry (1990) 29:8509-8517.
Wiedenmann et al. “Cracks in the B-Can: Fluorescent Proteins from Anemonia Sulcata (Anthozoa, Actinaria)” PNAS (2000) 97(26):14091-14096.
Wiedermann et al., Jarhrestagung der Deutschen Gesellschact furTropenokologie-gto. Ulm. Feb. 17-19, 1999. Poster P-4.20.
Wiehler et al. “Mutants of Discosoma Red Fluorescent Protein with a GFP-Like Chromophore,” FEBS Letter (2001) 487:384-389.
Wetzel “Mutations and Off-Pathway Aggregation of Proteins,” Tibtech (1994) 12:193-198.
Yang et al. “Optimized Codon Usage and Chromophore Mutations Provide Enhanced Sensitivity with the Green Fluorescent Protein,” 24(22):4592-4593.
Yarbrough et al., Proc Natl Acad Sci U S A (2001) 98:462-7.
Fradkov Arcady F.
Labas Yulii A.
Lukyanov Sergey A.
Matz Mikhail V.
Terskikh Alexey
Bozocevic, Field & Francis LLP
Clontech Laboratories, Inc
Field Bret E.
Robinson Hope
LandOfFree
Nucleic acids encoding chromophores/fluorophores and methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acids encoding chromophores/fluorophores and methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding chromophores/fluorophores and methods... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2794434