Nucleic acids encoding chimeric T cell receptors

Details Nucleic acids encoding chimeric T cell receptors Nucleic acids encoding chimeric T cell receptors

2003-05-28

2008-11-04

Ouspenski, Ilia (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023530

Reexamination Certificate

active

07446190

ABSTRACT:
Chimeric T cell receptors (TCR) are provided that combine, in a single chimeric species, the intracellular domain of CD3 ζ-chain, a signaling region from a costimulatory protein such as CD28, and a binding element that specifically interacts with a selected target. When expressed, for example in T-lymphocytes from the individual to be treated for a condition associated with the selected target, a T cell immune response is stimulated in the individual to the target cells. The chimeric TCR's are able to provide both the activation and the co-stimulation signals from a single molecule to more effectively direct T-lymphocyte cytotoxicity against the selected target and T-lymphocyte proliferation.

REFERENCES:
patent: 4675287 (1987-06-01), Reisfeld et al.
patent: 4769331 (1988-09-01), Roizman et al.
patent: 4859587 (1989-08-01), Roizman
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5302370 (1994-04-01), Neumeier et al.
patent: 5328688 (1994-07-01), Roizman
patent: 5359046 (1994-10-01), Capon et al.
patent: 5405990 (1995-04-01), Burke et al.
patent: 5585096 (1996-12-01), Martuza et al.
patent: 5686281 (1997-11-01), Roberts
patent: 5728379 (1998-03-01), Martuza et al.
patent: 6051428 (2000-04-01), Fong et al.
patent: 6344445 (2002-02-01), Boursnell et al.
patent: 2003/0077249 (2003-04-01), Bebbington et al.
patent: WO96/29421 (1996-09-01), None
patent: WO97/00085 (1997-01-01), None
patent: WO97/34634 (1997-09-01), None
Kroczek et al., 2005, J. Allergy Clin. Immunol, 116: 906-909.
Clarkson et al., 2005, Transplantation, 80: 555-563.
Oki et al., 2005, Molecular Cell, 19: 707-716.
Maher et al., 2002, Nature Biotechnology, 20: 70-75.
Alvarez-Vallina et al., Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors, Eur. J. Immunol., 1996, pp. 2304-2309, vol. 26.
Amit et al., Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution, Science, 1986, pp. 747-753, vol. 233.
Dranoff et al., Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity, Proc. Natl. Acad. Sci. USA, 1993, pp. 3539-3543.
Feldhaus et al., A CD2/CD28 chimeric receptor triggers the CD28 signaling pathway in CTLL.2 cells, Gene Therapy, 1997, pp. 833-838, vol. 4.
Karpoff et al., Prevention of Hepatic Tumor Metastases in Rats with Herpes Viral Vaccines and γ-Interferon, J. Clin. Invest., 1997, pp. 799-804, vol. 99, No. 4.
Kutubuddin et al., Eradication of preexisting murine tumor using herpes amplicon vectors, Cancer Gene Therapy, 1997, pp. S26 XP002073450, vol. 4, No. 6.
Lewin, Genes IV, 1990, pp. 810, Publisher: Oxford University Press.
Panka et al., Variable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies, Proc. Natl. Acad. Sci. USA, 1988, pp. 3080-3084, vol. 85.
Parijs, Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off, Science, 1998, pp. 243-248, vol. 280.
Paul, Fundamental Immunology , 1993, pp. 553-554, Publisher: Raven Press.
Rudikoff et al., Single amino acid substitution altering antigen-binding specificity, Proc. Natl. Acad. Sci. USA, 1982, pp. 1979-1983, vol. 79.
Sambrook, Molecular Cloning, a Laboratory Manual, 1989, pp. 16.9 & 16.11, Publisher: Cold Spring Harbor Laboratory.
Tung et al., Rapid Production of Interleukin-2-Secreting Tumor Cells by Herpes Simplex Virus-Mediated Gene Transfer: Implications for Autologous Vaccine Production, Human Gene Therapy, 1996, pp. 2217-2224, vol. 7.
Hellstrom et al., Tumor vaccines—a reality at last?, Journal of Immunotherapy, 1998, pp. 119-126, vol. 21, No. 2.
Stevenson FK., Tumor vaccines, FASEB J., 1991, pp. 2250-2257, vol. 5, No. 9.
Vieweg et al., Considerations for the use of cytokine-secreting tumor cell preparations for cancer treatment, Cancer Investigation, 1995, pp. 193-201, vol. 13, No. 2.

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