Nucleic acids encoding artificial P-selectin ligands

Details Nucleic acids encoding artificial P-selectin ligands Nucleic acids encoding artificial P-selectin ligands

2008-07-15

2008-07-15

Ewoldt, G. R. (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S252300, C435S320100

Reexamination Certificate

active

07399847

ABSTRACT:
Disclosed herein are organic molecules to which are covalently bonded a sialyl-Lexdeterminant and a sulfated determinant, at least one of these determinants being positioned at a non-naturally occurring site on the molecule. Also disclosed are particular P-selectin ligands and P-selectin ligand-antibody fusions. These molecules, ligands, and fusion proteins find use in methods of reducing or protecting against inflammation and extravasation-dependent adverse reactions, such as organ damage and clotting (for example, associated with adult respiratory distress syndrome or ischemic myocardial injury).

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