Nucleic acids encoding antigens associated with polymyositis and

Details Nucleic acids encoding antigens associated with polymyositis and Nucleic acids encoding antigens associated with polymyositis and

1992-11-10

2000-12-12

Sisson, Bradley L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 435 6, 436 94, C07H 2104, C12Q 168, G01N 3300

Patent

active

061601071

ABSTRACT:
Proteins including at least one epitope of the Mi-2 antigen, which are used for the diagnosis of dermatomyositis, and proteins including at least one epitope of the PM-Scl antigen, which are used for the diagnosis of polymyositis, particularly polymyositis-scleroderma overlap disorders are provided in an easily purified form for use in immunoassays and purification of the associated autoantigens. DNA that encode these proteins and that may also be used in diagnostic assays or as probes to obtain related DNA are also provided.

REFERENCES:
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J. Mol. Endocrinol. 1, 5-11 (19

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