Nucleic acids encoding anti-human ανβ3 and...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C536S023500, C536S023530, C435S069600, C435S320100, C435S325000, C530S387300, C530S388220

Reexamination Certificate

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07087405

ABSTRACT:
This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to a human αvsubunit-containing heterodimeric integrin receptors and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of disorders mediated by such receptors, such as cancer, in human patients.

REFERENCES:
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patent: WO 97/06791 (1997-02-01), None
patent: WO 99/55369 (1999-11-01), None
Burgess et al, Journal of Cell Biology vol. 111 Nov. 1990 2129-2138.
Lazar et al Molecular and Cellular Biology Mar. 1988 vol. 8 No. 3 1247-1252.
Schwartz et al, Proc Natl Acad Sci USA vol. 84:6408-6411 (1987.
Lin et al Biochemistry USA vol. 14:1559-1563 (1975.
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979.
1993/94 Promega Catalog.
Cabilly et al (Proc. Natl. Acad. Sci. USA 81:3273-3277, 1984.

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