Nucleic acids encoding antagonists of interleukin-15

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S069520, C435S069700, C435S252300, C435S254110, C435S320100, C435S471000, C435S071100, C435S071200, C435S325000, C530S351000, C530S402000

Reexamination Certificate

active

06998476

ABSTRACT:
Disclosure herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.

REFERENCES:
patent: 5011684 (1991-04-01), Strom
patent: 5116964 (1992-05-01), Capon et al.
patent: 5262522 (1993-11-01), Gearing
patent: WO 88/07089 (1988-09-01), None
patent: WO 95/27722 (1995-10-01), None
patent: WO 96/04306 (1996-02-01), None
patent: WO 96/26274 (1996-08-01), None
Akatsuka et al., “Synovial Mononuclear Cells Consist with T Cells Which Produce High Level . . . ” Microbiol. Immunol., 41:4, 367-370 (1997).
Anderson et al., Functional Characterization of the Human Interleukin-15 Receptor . . . J. Bio. Chem. 270:29862-29869 (1995).
Armitage et al., IL-15 Has Stimulatory Activity for the Induction of B Cell Proliferation and Differentiation, J. Immunology, 154:483-490 (1995).
Bamford et al., The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T . . . Proc. Nat. Acad. Sciences 91:4940-4944 (1994).
Blanar et al., “Interaction Cloning: Identification of a Helix-Loop-Helix Zipper Protein That Interacts with c-Fos”, Science 256:1014-1018 (1992).
Brekke et al., Structure-Function Relationships of Human IgG, The Immunologist 2:125-130 (1994).
Burger et al., “Imbalance between intersitital collagenase and tissue inhibitor of metalloproteinase I . . . ”, Arthritis & Rheumatism 41:10 (1998).
Burton et al., A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line . . . Proc. Nat. Acad. Sciences 91:4935-4939 (1994).
Carson et al., Interleukin (IL) 15 Is a Novel Cytokine That Activates Human Natural Killer Cells via Components of the IL-2 Receptor, J. Exper. Medicine 180:1395-1403 (1994).
Chae et al., “Mutant IL-15 Protein Exerting Antagonistic Effects on IL-15 Triggered Cell Proliferation”, J. American Society of Nephrology 7:1654 (1996).
Chae et al., Distribution of IL-15 Receptor a-Chains on Human Peripheral Blood Mononuclear Cells and Effect of . . . American Association of Immunologists (1996).
Courtenay et al., “Immunisation against heterologous type II collagen induces arthritis in mice”, Nature 283:5748 (1980).
Cunningham et al., “High-Resoluction Epitope Mapping of HGH-Receptor . . . ” Science 244, 1081-1085 (1989).
Elliott et al., “Repeated therapy with monoclonal antibody to tumour necrosis factor . . . ” Lancet 344:8930 (1994).
Elliott et al., “Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor . . . ” Lancet 344:8930 (1994).
George et al., “Current methods in sequence comparison and analysis”, Macromolecular Sequencing and Synthesis Selected methods and Applications, p127-149 (1988).
Giri et al., “IL-15, A Novel T Cell Growth Factor That Shares Activities and Receptor Components with IL-2”, J. Leukocyte Biology, 57:763-766 (1995).
Giri et al., “Identification and cloning of a novel IL-15 binding protein that is structurally related to . . . ” EMBO Journal 14:3654-3663 (1995).
Giri et al., Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15, EMBO Journal 13:2822-2830 (1994).
Grabstein et al., Cloning of a T Cell Growth Factor That Interacts . . . Science 264:965-968 (1994).
Hatakeyama et al., A Restricted Cytoplasmic Region of IL-2 Receptor . . . Cell 59:837-845 (1989).
Kim et al., Targeting the Il-15 Receptor with an Antagonist IL-15 Mutant/Fcγ2a Protein Blocks Delayed-type Hypersensitivity Journal of Immunology 160:5742-5748 (1998).
Isler et al., “Cell surface glycoproteins expressed on activated human T cells induce production of interleukin-1 beta by monocytic cells: a possible role of CD69” Eur. Cytokine Netw., 4:1 15-23, (1993).
Knight et al., “Construction and initial characterization of a mouse-human chimeric anti-TNF antibody” Molecular Immunology 30:16, 1443-1453 (1993).
LeClair et al., The p50 subunit of NF-κB associates with the NF-IL6 transcription factor, Proc. Nat. Acad. Sciences 89:8145-8149 (1992).
Lin et al., The Role of Shared Receptor Motifs and Common Stat Proteins in the Generation of Cytokine. Immunity 2:331-339 (1995).
Maslinski et al., Interleukin-2 (IL-2) Induces Tyrosine Kinase-dependent Translocation of Active. J. Biological Chemistry 267:15281-15284 (1992).
Maslinski et al., Intoxication of high affinity IL-2 receptor positive thymocytes blocks early stages of T cell maturation, International Immunology 4:509-517 (1992).
Moreland et al., Treatment of Rheumatoid Arthritis with A Recombinant Human Tumor Necrosis Factor Receptor (p75)-Fc Fusion Protein NEJM 337:3, 141-147 (1997).
Miltenburg et al., “Immobilized Anti-CD3 Antibody Activates T Cell Clones to Induce the Production of Interstitial Collagenase, but Not Tissue Inhibitor . . . ” The Journal of Immunology 154:6 (1995).
Morrison et al., Structural Determinants of Human IgG Function, The Immunologist 2:119-124 (1994).
Nickerson et al., Prolonged Islet Allograft Acceptance in the Absence of Interleukin 4 Extression; Transplant Immunology, 4:81-85 (1996).
Pettit et al., Structure-Function Studies of Interleukin 15 using Site-specific Mutagenesis, Polyethylene Glycol . . . J. Biological Chemistry, 2312-2318 (1997).
Pettit et al., “Polyethylene Glycol Conjugation to Lysine Residues of Recombinant IL-15 Generates a Specific Il-15 Antagonist”, Pro. of the Int. Symp. on Cont. Release Bioactive Materials: 22;496/497 (1995).
Remillard et al., Interleukin-2 Receptor Regulates Activation of Phosphatidylinositol 3-Kinase, Journal of Biological Chemistry 266:14167-14170 (1991).
Rezzonico et al., “Direct Contact between T Lymphocytes and Human Dermal Fibroblasts or Synoviocytes”, Journal of Biological Chemistry 273:30, 18720-18728 (1998).
Stevens et al., Interleukin-15 signals T84 colonic epithelial cells . . . The American Physiological Society (1997).
Williams et al., “Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anit-CD4” Immunology 84:3, 439—439 (1995).
Wooley et al., “Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice” The Journal of Immunology 151:11, 6602-6607 (1993).
Vey et al., “IFN-γ and 1,25 (OH)2D3Induce on THP-1 Cells Distinct Patterns of Cell of Surface Antigen Expression . . . ”, The Journal of Immunology 149:6, 2040-2046 (1992).

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