Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-07
1999-01-05
Spector, Lorraine M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 2351, 435325, 435360, 4352523, 935 13, C12N 1516
Patent
active
058561374
ABSTRACT:
Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.
REFERENCES:
patent: 4363877 (1982-12-01), Goodman et al.
patent: 4383034 (1983-05-01), Sugimoto
patent: 4383035 (1983-05-01), Sugimoto
patent: 4383036 (1983-05-01), Sugimoto
patent: 4394443 (1983-07-01), Weissman et al.
patent: 4401759 (1983-08-01), Rubin et al.
patent: 4405712 (1983-09-01), Vandewoude et al.
patent: 4419446 (1983-12-01), Howley et al.
patent: 4442205 (1984-04-01), Hamer et al.
patent: 4468464 (1984-08-01), Cohen et al.
patent: 4656134 (1987-04-01), Ringold
patent: 4704362 (1987-11-01), Itakura et al.
patent: 4717670 (1988-01-01), Beck
patent: 4816397 (1989-03-01), Boss et al.
patent: 4840896 (1989-06-01), Reddy et al.
patent: 4923805 (1990-05-01), Reddy et al.
The Merck Index, Stecher et al Merck & Co., Inc. 1052 (1968).
Biotech Newswatch, :7 (Mar. 7, 1983).
Biotech Newswatch, :3 (Jan. 16, 1984).
Biotech Newswatch, :3-4 (Jun. 20, 1983).
Biotechnology, :753-755 (1984).
Chem. Eng. News, 61:41 (Nov. 21, 1983).
Genetic Eng. Letter, :4 (Aug. 10, 1984).
Genetic Eng Letter, :4 (Dec. 10, 1983).
Genetic Tech News, :7 (1983).
Genetic Tech News, :9 (1982).
Genetic Tech News, : (Dec. 00,1983).
Genetic Tech. News, 2:3 (1982).
Scrip, 877:18 (Mar. 7, 1984).
(transl'n of) Judgement dated Apr. 1, 1993 of the Court of Appeal in the Hague (Applied Research Systems v. Organon), 1993.
Agrawal et al., J. Gen. Virol., 73:201-206 (1992).
Albert et al, J Clin Endocrinol Metab, 28:1214-1219 (Aug. 00, 1968).
Allshire et al, J. Mol. Biol., 188:1-13 (1986).
Allshire et al, Virus Research, 6:141-154 (1986).
Amtmann et al., J Virol, 35:962-964 (Aug. 00, 1980).
Anderson et al, PNAS, 78:5598-5602 (Sep. 00, 1981).
Anderson et al., PNAS, 80:6838-6842 (Nov. 00, 1983).
Anfinsen, Science, 181:223-230 (1973).
Ashitaka, Acta Obst et Gyn Jap, 17:124-135 (1970).
Ashitaka et al, Endocrinol, 87:233-244 (1970).
Ashitaka et al, Endocrinol, 90:609-617 (1972).
Asselbergs et al, Eur J Biochem, 91:65-72 (1978).
Bahl et al, Biochem Biophys Res Comm, 48:416-422 (1972).
Banerji et al, Cell, 27:299-308 (1981).
Barr et al, J Endocr, 38:395-399 (1967).
Beck et al., 7th Int'l Cong Endoc, :308 (1984).
Beck et al., DNA, 4:76 (Jan. 21, 1985).
Bellisario et al, J Biol Chem, 248:6796-6809 (1973).
Bendig, Protein Production of Biotech., Harris et al 79-98 (1990).
Bergman et al., Gene, 50:185-193 (1986).
Blattner et al., Science, 196:161-169 (1977).
Bogdanove et al., Endo, 95:219-228 (1974).
Borth et al, Archiv fur Gynakologie, 188:497-538 (1957) In German, No Translation.
Boulianne et al., Nature, 312:643-646 (Dec. 12, 1984).
Braunstein et al, Annals Int Med, 78:39-45 (1973).
Braunstein et al, Biochem Biophys Res Comm, 42:962-967 (1971).
Breathnach, EMBO J, 3:901-908 (1984).
Brennand et al, J Biol Chem, 258:9593-9596 (1983).
Brown, Aust N Z J Obstet Gynaec, 18:47-54 (1978).
Burke et al, Cell, 36:847-856 (Apr. 00, 1984).
Burke et al, EMBO J, 3:551-556 (1984).
Burrell et al, Nature, 279:43-47 (1979).
Cabilly et al., PNAS, 81:3273-3277 (1984).
Carloni et al, Gene, 31:49-57 (1984).
Carlsen et al, J Biol Chem, 248:6810-6827 (1973).
Chappel et al., Endocrine Reviews, 4:179-211 (1983).
Chen et al, J Biol Chem, 257:14446-14452 (Dec. 10, 1982).
Chin et al, Endocrinol, 108:1628-1633 (1981).
Chou, PNAS, 75:1854-1858 (1978).
Christman et al, PNAS, 79:1815-1819 (1982).
Church et al, Proc Natl Acad Sci USA, 81:1991-1995 (Apr. 00, 1984).
Closset et al., Eur. J. Biochem., 86:115-120 (1978).
Collen et al, J Pharmacol Exp Ther, 231:146-152 (1984).
Colman et al, Eur J Biochem, 113:339-348 (1981).
Corbani et al, Mol Cell Endocrinol, 35:83-87 (1984).
Counis et al, 7th Int'l Cong. Endocrinol: Abstracts, Excerpta Medica 448 (1984).
Cox et al, Am J Med Sci, 275:232-248 (1978).
Creighton, J Mol Biol, 144:521-550 (1980).
Cumming, Glycobiology, 1:115-130 (1991).
Davis et al., PNAS, 80:3976-80 (Jul. 00, 1983).
Denniston et al, Gene, 32:357-368 (1984).
Derynck et al, Nucleic Acids Res, 11:1819-(1983).
Devos et al, Nucleic Acids Res, 10:2487-2501 (1982).
Di Maio, PNAS, 79:4030-4034 (1982).
DiMaio et al, Mol Cell Biol, 4:340-350 (Feb. 00, 1984).
Doms et al, J Cell Biol, 5:179a (1983).
Dubois et al, PNAS, 77:4549-4553 (1980).
Dufau et al, Biochem Biophys Res Comm, 44:1022 -1029 (1971).
Edwards et al, The Lancet, 2:1265-1269 (Dec. 3, 1983).
Elder et al, Ann Rev Genet, 15:295-340 (1981).
Faiman et al, J Clin Endo Metab, 27:444-447 (1967).
Faiman et al, New Eng J Med, 277:1395-1399 (1967).
Fathalla, The Lancet, 2:163 (1971).
Faulkner et al, Nature, 298:286-288 (Jul. 15, 1982).
Fein et al, J Clin Endocr Metab, 50:1111-1120 (1980).
Fiddes et al, J. Mol. Appl. Genet., 1:3-18 (1981).
Fiddes et al, Nature, 281:351-356 (Oct. 4, 1979).
Fiddes et al, Nature, 286:684-687 (Aug. 14, 1980).
Fiers et al, Primary and Tertiary Structure . . . , Miwa et al Japan Sci Soc Press 227-236 (1982).
Flamigni et al, Contracept Fertil Sexual, 13:1097-1101 (1985).
Fujiki et al., J. Biol. Chem., 253:5363-5368 (1978).
Fukunaga, R., PNAS, 81:5086-5090 (Aug. 00, 1984).
Garcia et al, Fertility and Sterility, 44:478-483 (Oct. 00, 1985).
Garoff et al, J Cell Biol, 97:652-658 (1983).
Garoff et al, J Mol Biol, 124:587-600 (1978).
Garoff et al, Nature, 274:487-490 (1978).
Germain et al, Nature, 306:190-194 (Nov. 10, 1983).
Gething et al., Nature, 300:598-603 (Dec. 16, 1982).
Gheysen et al, J Mol Appl Genet, 1:385-394 (1982).
Ghosh et al, Am. J. Hum. Genet., 29:46A (1977).
Ghosh et al, Nature, 267:435-437 (1977).
Gibson et al, TIBS, 5:290-293 (1980).
Giudice et al, Biochem Biophys Acta, 533:140 (1978).
Giudice et al, J Biol Chem, 251:6392 (1976).
Gluzman, Cell, 23:175-182 (1981).
Godine et al, J Biol Chem, 255:8780-8783 (1980).
Goodenow et al, Nature, 301:388-394 (Feb. 3, 1983).
Gorman et al, PNAS, 79:6777-6781 (1982).
Gouch et al, J Mol Biol, 162:43-67 (1982).
Goverman et al, J Biol Chem, 257:15059-15064 (Dec. 25, 1982).
Graham et al., Virology, 52:456-467 (1973).
Grantham et al., Nucl. Acids Research, 9:43-73 (1981).
Gray et al., Nature, 295:503-508 (Feb. 11, 1982).
Gruss et al, PNAS, 78:133-137 (1981).
Gunning et al, Cell, 36:709-715 (1984).
Gupta et al, J Biol Chem, 260:2941-2944 (1986).
Ham et al., Methods Enzymol, 58:44-93 (1979).
Hamer et al, J Mol Appl Gen, 1:273-288 (1982).
Hanover et al, Arch Biochem Biophys, 211:1-19 (1981).
Hartman et al, PNAS, 79:233-237 (Jan. 00, 1982).
Heilman, Virology, 119:22-34 (1982).
Heine et al., J Gen Virol, 44:45-55 (1979).
Hitzeman et al, Nature, 293:717-722 (Oct. 29, 1981).
Hitzeman et al, Nucleic Acid Res, 11:2745-2763 (1983).
Howard, TIBS, :209-212 (1983).
Howley et al, Methods Enzymol, 101:387-402 (1983).
Hsiung et al, J Mol App Genet, 2:497-506 (1984).
Hsiung et al, Mol Cell Biol., 2:401-411 (1982).
Hsueh et al, Endocrine Rev, 5:76-127 (1984).
Hubbard et al, Ann Rev Biochem, 50:555-583 (1981).
Hussa et al, J Clin Endocri Metab, 46:6976 (1978).
Jaenicke, Biophys Struct Mech, 8:231-256 (1982).
Jaye et al., Nucl Acids Res, 11:2325-2335 (1983).
Jia et al, Neuroendocrinol, 41:445-448 (1985).
Jones et al, Fertil Steril, 38:14-21 (Jul. 00, 1982).
Julius et al, Cell, 36:309-318 (1984).
Kaetzel et al, J Biol Chem, 263:6344-6351 (May 5, 1988).
Kaetzel et al, PNAS, 82:7280-7283 (Nov. 00, 1985).
Kahn et al, New Eng J Med, 297:565-569 (1977).
Kalyan et al, J Biol Chem, 258:67-74 (Jan. 10, 1983).
Kao et al, PNAS, 60:1275-1281 (1968).
Karin et al, Cell, 36:371-379 (1984).
Kato, Mol Cell Endocrinol, 55:107-112 (1988).
Kaufman et al, J Mol Biol, 159:601-621 (1982).
Kaufman et al, Mol Cell Biol, 2:1304-1319 (1982).
Kaufman et al, Mol Cell Biol, 5:1750-1759 (Jul. 00, 1985).
Keene et al, J. Biol. Chem., 264:4769-4775 (1989).
Kenigsberg et al, Fertility and Sterility, 42:116-126 (Jul. 00, 1984).
Kenter et al, J Cell Biol, 98:2215-2221 (1984).
Keutmann et al, Biochem, 22:3067-3072 (1983).
Kimuri et al, Virology, 4
Beck Anton K.
Berstine Edward George
Hsiung Nancy
Reddy Vermuri B.
Genzyme Corporation
Spector Lorraine M.
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