Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reissue Patent
2007-05-09
2009-10-13
Myers, Carla (Department: 1634)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024310
Reissue Patent
active
RE040937
ABSTRACT:
A method for the early diagnosing of selected adenocarcinomas in a human comprising the steps of removing a bodily sample from the human, and assaying the bodily sample for elevated expression of a specific gene. The gene being assayed for in the bodily sample is the TGFB-4 gene (hereinafter referred to as the endometrial bleeding associated factor (ebaf) gene. The bodily sample can be tissue from a specific organ in the body, or a blood sample. Increased levels of ebaf in the sample relative to basal levels may be indicative of a mucinous adenocarcinoma of the colon or ovaries, or an adenocarcinoma of the testis.
REFERENCES:
patent: 4444879 (1984-04-01), Foster et al.
patent: 5286624 (1994-02-01), Terashima et al.
patent: 5395825 (1995-03-01), Feinberg et al.
patent: 5420016 (1995-05-01), Boguslaski et al.
patent: 5554339 (1996-09-01), Cozzette et al.
patent: 5616561 (1997-04-01), Barcellos-Hoff
patent: 5693479 (1997-12-01), Feinberg et al.
patent: 5709837 (1998-01-01), Mori et al.
patent: 5874479 (1999-02-01), Martin
patent: 5916751 (1999-06-01), Tabibzadeh et al.
patent: 6027917 (2000-02-01), Celeste et al.
patent: 6040431 (2000-03-01), Keck et al.
patent: 6242568 (2001-06-01), Barbas et al.
patent: 6294662 (2001-09-01), Tabibzadeh
patent: 6428966 (2002-08-01), Lee et al.
patent: 6492497 (2002-12-01), Thompson et al.
patent: 6635480 (2003-10-01), Lee et al.
patent: 6649588 (2003-11-01), Tabibzadeh et al.
patent: 6677432 (2004-01-01), Oppermann et al.
patent: 6683156 (2004-01-01), Tabibzadeh
patent: 6747004 (2004-06-01), Tabibzadeh
patent: 7211644 (2007-05-01), Tabibzadeh
patent: 2003/0022841 (2003-01-01), Lee et al.
patent: 2003/0032047 (2003-02-01), Tabibzadeh
patent: 2003/0064069 (2003-04-01), Thompson et al.
patent: 2003/0091566 (2003-05-01), Thompson et al.
patent: 2005/0276802 (2005-12-01), Adams et al.
patent: 2007/0172870 (2007-07-01), Tabibzadeh
patent: 2008/0200379 (2008-08-01), Tabibzadeh
patent: WO 99/06443 (1999-02-01), None
patent: WO 99/06444 (1999-02-01), None
patent: WO 99/55902 (1999-11-01), None
patent: WO 01/01134 (2001-01-01), None
Kosaki et al. American Journal of Human Genetics. 1999. 64: 712-721.
GeneCard for ebaf/lefty2, available via url:<genecards.org/cgi-bin/carddisp.pl?gene=LEFTY2>.
“DNA Sequencing by the Dideoxy Method,” Sequences Ver. 2.0 A New Genetically Engineered Enzyme for DNA Sequencing, U.S. Biochemical Corp., 1988-89, pp. 7-29-7-35.
Brown “Analysis of RNA by Northern and Slot Blot Hybridization” Current Protocols in Molecular Biology, Unit 4.9, 1993, pp. 4.9.1-4.9.14.
Liang et al. “Differential Display Using One-Base Anchored Oligo-dT Primers”Nucleic Acids Research, 1994, pp. 5763-5764, vol. 22, No. 25.
Tabibzadeh et al. “Distinct Tumor Specific Expression of TGFB4 (ebaf), a Novel Human Gene of the TGF-B Superfamily”Frontiers in Bioscience 2, Jul. 1997, pp. 18-25.
Tabibzadeh et al. “Dysregulated Expression of ebaf, a Novel Molecular Defect in the Endometria of Patients with Infertility”The Journal of Clinical Endocrinology&Metabolism, Mar. 8, 2000, pp. 2526-2536, vol. 85, No. 7.
Tabibadeh et al. “Temporal and Site-Specific Expression of Transforming Growth Factor-β4 in Human Endometrium”Molecular Human Reproduction, 1998, pp. 595-602, vol. 4, No. 6.
“Radioimmunoassay”, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/Radioimmunoassay.html, Mar. 2005, pp. 1-3.
Lennard, S.N., et al., “Transforming growth factor beta 1 expression in the endometrium of the mare during placentation”Molecular Reproduction and Development, 1995, pp. 131-140, vol. 42.
Wieczorek, Z., et al., “The immunomodulatory diversity of the proteins of the transforming growth B (TGFB) family”International Journal of Peptide and Protein Research, Jul. 1995, pp. 113-118, vol. 46.
Burt, D.W., et al., “Multiple growth factor mRNAs are expressed in chicken adipocyte precuror cells”Biochemical and Biophysical Research Communications, Sep. 30, 1992, pp. 1298-1305, vol. 187, No. 3.
Bowie, James U., et al., “Deciphering the Message in Protein Sequences: Tolerance to amino acid substitution”Science, Mar. 16, 1990, pp. 1306-1310, vol. 247.
Meno, et al., “Left-right asymmetric of the TFGβ—family member lefty in mouse embryos”Nature1996, pp. 151-155, vol. 381.
Sporn, M.B., et al., “TFGβ: problems and prospects”,Cell Regulation, The American Society of Cell Biology, Nov. 1990, pp. 875-882.
Roberts, A.B., “Transforming growth factor β: multifunctional regulator of differentation and development”,Phil. Trans. R. Soc. Lond. B, 1990, pp. 145-154, vol. 327.
Burt, David W., et al., Correction: A New Interpretation of a Chicken Transforming Growth Factor—β4 Complementary DNA,Molecular Endorcrinology, pp. 989-992, vol. 6, No. 6.
Flanders, Kathleen C., et al., “Antibodies to peptide determinants in Transforming Growth Factor B and their Applications”Biochemistry1988, pp. 739-746, vol. 27.
Postlethwaite, A.E., et al., “Identification of a chemotactic Epitope in Human Transferring Growth Factor-β1 Spanning Amino Acid Residues 368-374”,Journal of Cellular Physiology, 1995, pp. 587-592, vol. 164.
Teicher, B.A., et al., “Transforming growth factor—βin vivo resistance”,Cancer Chemther Pharmacol1996, pp. 601-609, vol. 37.
Newcom, Samuel, R., et al., “Production of Monoclonal Antibodies That Detect Hodgkin's High Molecular Weight Transforming Growth Factor—β”Blood, Jun. 15, 1990, pp. 2434-2437, vol. 75, No. 12.
Dillner, J., et al., “Antibodies Against a Synthetic Peptide (Gly-Ala)”PNAS, Aug. 1984, pp. 4652-4656, vol. 18.
Oosterlynck, D.J., et al., “Transforming growth factor B activity is increased in peritoneal fluid from women with endometriosis”Obstet. Gynecol, Feb. 1994, pp. 287-292, vol. 83, No. 2.
Ayala, A., et al., “The release of transforming growth factor B following hemorrhage: its role as a mediator for host immunosuppression”Immunology, 1993, pp. 479-484, vol. 79.
Hoefer, M., et al., “Anti (transforming growth factor B) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu
u mice”Cancer Immunol Immunother, 1995, pp. 302-308, vol. 41.
U.S. Appl. No. 11/801,428, filed May 9, 2007, Tabibzadeh.
RNA Image Kit Product Brochure, 1993, pp. 1-21.
“DNA Sequencing by the Dideoxy Method,” Sequences Ver. 2.0 A New Genetically Engineered Enzyme for DNA Sequencing U.S. Biochemical Corp., 1988-89, pp. 7-29-7-35, p. 7.29 only.
Analysis of RNa by Northern and Slot Blot Hybridization, Current Protocols in Molecular Biology, Unit 4.9, Unit 4.9, 1993, pp. 4.9.1-4.9.14, p. 4.9.1 only.
Hillier et al. Genbank Accession No. R37562, May 1995.
Frigerio et al. Genbank Accession No. T25016, May 1995.
Liang et al. “Differential Display Using One-Base Anchored Oligo-dT Primers”Nucleic Acids Research, 1994, pp. 5763-5764, vol. 22, No. 25. p. 5763 only.
Tabibzadeh et al.“District Tumor Specific Expression of TGFB4 (ebaf), a Novel Human Gene of the TGF-B Superfamily”Frontiers in Bioscience 2, Jul. 1997, pp. 18-25. p. 18 only.
Tabibzadeh et al. “Dysregulated Expression of ebaf, a Novel Molecular Defect in the Endometria of Patients with Infertility”The Journal of Clinical Endocrinology&Metabolism, Mar. 8, 2000, pp. 2526-2536, vol. 85, No. 7,. p. 2526 only.
Tabibzadeh et al., “Temporal and Site-Specific Expression of Transforming Growth Factor-β4 in Human Endometrium”Molecular Human Reproduction, 1998, pp. 595-602, vol. 4, No. 6. p. 595 only.
“Radioimmunossay”, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/Radioimmunossay.html, Mar. 2005, pp. 1-3. p. 1 only.
Capecchi, M.R., “Altering the Genomome by Homologous Recombination”Science, 1989, pp. 1288-1292, v
Kothapalli Ravi
Tabibzadeh Siamak
Myers Carla
Saliwanchik Lloyd & Saliwanchik
University of South Florida
LandOfFree
Nucleic acids encoding an endometrial bleeding associated... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acids encoding an endometrial bleeding associated..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding an endometrial bleeding associated... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4117014